권재영 교수님(Jae Young Kwon)

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작성일 21-04-27 17:24

본문

	권재영 (Kwon, Jae Young)
	직함	교수, Professor
	전공	생물학, Molecular neurogenetics
	연구실	신경유전학연구실, Neurogenetics lab
	전화	031-299-4495
	사무실	제2과학관 32257
	홈페이지	https://sites.google.com/view/neurogenetics-skku/home
	이메일	jykwon@skku.edu

연구실 소개

연구 분야: 우리 연구실은 동물 행동을 결정하는 유전자들의 역할을 연구합니다. 초파리 화학감각 시스템을 모델로 이용하여, 외부 환경을 감지해서 행동에 이르는 일련의 과정을 연구하고 있습니다.

응용 분야 또는 산물: 증명가능한 질문과 이에 접근가능한 실험 방법을 연구함으로써, 복잡하게만 보이는 뇌신경계를 이해하기 위한 기반을 마련합니다.

연구실 홈페이지: https://sites.google.com/view/neurogenetics-skku/home

Research Background

Chemosensory Perception in Drosophila

All animals are born with a set of instincts, or innate behaviors, and our main questions are how complex behaviors are organized in the nervous system and how they are programmed during development. For this, the chemosensory system would be one of the most excellent models. Smell and taste are known to be important for sensing predators, selecting mates as well as finding food. We would like to trace the neuronal pathways that mediate a complex instinctive behavior such as feeding, from sensory input through to motor output. We are using the fruit fly as a model system to study chemosensation.

Functional study of chemosensory system in Drosophila larva

We aim to identify molecular and cellular components required for chemosensation such as chemosensory receptors, chemosensory neurons, and the downstream signaling pathways, as well as elucidate the process starting from chemosensory perception and ending in a motor reaction. Drosophila melanogaster larvae are used as a simple model system to gain insight into these processes. Through these studies we aim to establish a molecular neurogenetic understanding of how external stimuli is perceived and processed in the peripheral and central nervous system.

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Dissecting the interaction between nutrient sensing and homeostasis

The propose of this study is the identification of novel function of chemosensory receptors in Drosophila melanogaster. Specifically, we are interested in the role of chemoreceptors in homeostatic maintenance.

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Selected Publications

• Sung HY, Jeong YT, Lim JY, Kim H, Oh SM, Hwang SW, Kwon JY*, Moon SJ*. Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds. Nat Commun. (2017) Nov 14;8, 1484

• Lee MJ, Sung HY, Jo H, Kim HW, Choi MS, Kwon JY*, Kang K*. Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in Drosophila. Mol Cells. (2017) Oct;40(10):787-795.

• Kim H, Jeong YT, Choi MS, Choi J, Moon SJ*, Kwon JY*. Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods. Mol Cells. (2017) May 31;40(5):331-338.

• Lim CM, Kwon JY*, Cho WJ*. Field-Effect Transistor Biosensor Platform Fused with Drosophila Odorant-Binding Proteins for Instant Ethanol Detection. ACS Appl Mater Interfaces. (2017) Apr 26;9(16):14051-14057.

• van Giesen L, Neagu-Maier GL, Kwon JY*, Sprecher SG*. A microfluidics-based method for measuring neuronal activity in Drosophila chemosensory neurons. Nat Protoc. (2016) Dec;11(12):2389-2400.

• Choi J, van Giesen L, Choi MS, Kang K, Sprecher SG*, Kwon JY*. A Pair of Pharyngeal Gustatory Receptor Neurons Regulates Caffeine-Dependent Ingestion in Drosophila Larvae. Front Cell Neurosci. (2016) Jul 19;10:181.

• Chen J, Kim SM, Kwon JY. A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells. Mol Cells. (2016) Apr 30;39(4):358-66.

• Park JH, Chen J, Jang S, Ahn TJ, Kang K, Choi MS*, Kwon JY*. A subset of enteroendocrine cells is activated by amino acids in the Drosophila midgut. FEBS Lett. (2016) Feb;590(4):493-500.

• Kim H, Choi MS, Kang K, Kwon JY. Behavioral Analysis of Bitter Taste Perception in Drosophila Larvae. Chem Senses. (2016) Jan;41(1):85-94.

• Chen J, Choi MS, Mizoguchi A, Veenstra JA, Kang K, Kim YJ*, Kwon JY*. Isoform-specific expression of the neuropeptide orcokinin in Drosophila melanogaster. Peptides. (2015) 68:50-7.

• Park J-H, and Kwon JY. Heterogeneous expression of Drosophila gustatory receptors in enteroendocrine cells. PLoS One. (2011) e29022.

• Park J-H, and Kwon JY. A systematic analysis of Drosophila gustatory receptor gene expression in abdominal neurons which project to the central nervous system. Mol. Cells (2011) 32(4):375-81.

Funding

• 2017 – 2020	Analysis of the differentiation and function of Drosophila enteroendocrine cells, National Research Foundation of Korea
• 2016 – 2019	Molecular and cellular basis of taste perception in Drosophila, National Research Foundation of Korea

Education and experiences

• 2018 -	Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2012 - 2018	Associate Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2008 - 2012	Assistant Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2003 - 2008	Postdoc, MCDB, Yale University (Mentor: John R. Carlson, Ph.D.)
• 2000 - 2003	Department of Biology, Yonsei University (Mentor: Junho Lee, Ph.D.)
• 2000 - 2003	Dissertation: “Genome-wide analysis of ethanol response genes in the nematode Caenorhabditis elegans”
• 1998 - 2000	M.S., Department of Biology, Yonsei University (Mentor: Junho Lee, Ph.D.) Master Thesis: “Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation”
• 1991 - 1998	B.A., Department of Biology, Yonsei University