Recent Publication

The repopulating cancer cells in melanoma are characterized by increas…

페이지 정보

작성자 관리자 댓글 0건 조회 493회 작성일 16-11-02 11:11

본문

The repopulating cancer cells in melanoma are characterized by increased mitochondrial membranepotential.

Abstract

Although considerable effort has been expended in identifying definitive markers for cancer stem cells (CSCs) or cancer-initiating cells (CICs), the phenotypic plasticity of these cells obviates simple characterization using cell surface markers. We hypothesized that these cells could be characterized by their metabolic properties because they are in a quiescent state with low energy needs. We examined whether cancer cells differ in mitochondrial membrane potential (Δψm) when they are under stress. The Δψm of B16-F10 melanoma cells increased when they were exposed in vitro to serum starvation and chemotherapeutic agents, but not when exposed to hypoxia. Such TMREhigh cells were also present in tumor tissue. They primarily used glucose and/or lactate, and were superior to TMRElow B16-F10 cells in their ability to drive tumor growth. These findings suggest that CSCs or CICs could be identified in heterogeneous melanoma populations by measuring Δψm

.

댓글목록

등록된 댓글이 없습니다.

Copyright 2021 © Designed by LHS, ALL RIGHT RESERVED