이대한 교수님(Lee, Daehan)
페이지 정보
작성일 23-02-20 14:08본문
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이대한 (Lee, Daehan) |
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직함 |
조교수 |
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전공 |
진화유전학 |
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연구실 |
Evomics Lab |
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전화 |
031-290-5923 |
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사무실 |
제2과학관 32158B호 |
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이메일 |
lee.daehan@skku.edu |
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홈페이지 |
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| 연구실 소개 |
진화생물학은 새로운 생물이 만들어지고 환경 변화에 따라 적응해가는 원리와 기작을 탐구하는 학문입니다. 저희 연구실(Evomics lab)은 다양한 생물 종을 대상으로 각종 오믹스 기법을 포함한 첨단 기술을 활용하여 생물의 진화를 연구하고 있습니다. 세부적으로는 신경계의 진화, 발생 프로그램의 리모델링(Evo-Devo), 공생 관계의 공진화 등과 같은 흥미로운 진화 현상의 유전적 기반과 분자적 기작을 규명해나가고 있습니다.
| Reseach Background |
At the Evomics Lab, our focus is on answering a fundamental question in evolutionary biology: how does natural selection construct and shape
complex biological systems? We employ cutting-edge omics tools and integrate diverse fields such as genetics, neuroscience, developmental biology,
ecology, and evolutionary biology to molecularly dissect the evolutionary processes that underlie the emergence of evolutionary novelties and
species' adaptation to changing environments.
Our research explores various model and non-model species, investgating subjects such as the origin of nervous systems, neurodevelopmental
renovation, developmental system adaptation, ecological specialization, and symbiotic multi-species coevolution. To investigate natural differences
among and within species, we use both fieldwork and laboratory experiments. Additionally, we establish experimental evolution platforms in the
laboratory to track evolutionary processes in real-time.
Our research programs aim to lay the groundwork for advancing evolutionary biology in the Omics era.
| Reseach Interests |
• Evo-Neuro Devo: Understanding developmental renovation underlying nervous system evolution (Research model: insect chemosensory systems)
• CeLTEE (C. elegans Long-Term Evolution Experiment): Establishing LTEE platform for multicellular system (Research model: C. elegans)
• Symbiotic coevolution: Uncovering evolution of Fig-Fig wasp-Fig nematode symbiosis
• On the origin of nervous system (Research model: Choanoflagellates)
| Academic Employments and Education |
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• 2023~Present : Assistant Professor, Department of Biological Sciences, Sungkyunkwan University |
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| • 2022 : Assistant Professor, Department of Biology, Kyung Hee University | |
| • 2020~2022 : Postdoctoral Fellow, Center for Integrative Genomics, University of Lausanne, Switzerland | |
| • 2020 : Research Assistant Professor, Department of Life Science, Hanyang University | |
| • 2017~2020 : Postdoctoral Fellow, Department of Molecular Biosciences, Northwestern University, USA | |
| • 2010~2017 : Ph.D., Department of Biological Sciences, Seoul National University | |
| • 2006~2010 : B.S., Department of Biological Sciences, Seoul National University |
| Professional Contributions |
| • 2023~Present : Executive Board Member, Korean Society for the Study of Evolution |
| Research Publication (Selected) |
• Zhang, G., Roberto, NM., Lee, D., Hahnel, S., Andersen, EC. (2022) The impact of species-wide gene expression variation on
Caenorhabditis elegans complex traits. Nature Communications. 13(1):1-13
• Lee, D.*, Zdraljevic, S.*, Stevens, L.*, Wang, Y., Tanny, RE., Crombie, TA., Cook, DE., Webster, AK., Chirakar, R., Baugh, LR., Sterken,
MG., Braendle, C., Félix, M-A., Rockman, MV. and Andersen, EC. (2021). Balancing selection maintains hyper-divergent haplotypes in
C. elegans. Nature Ecology & Evolution 5(6):794-807. (*equal contribution)
• Cho, B., Yoon, S-H., Lee, D., Koranteng, F., Tattikota, SG., Cha, N., Shin, M., Do, H., Hu, Y., Oh, SY., Lee, D., Menon, AV., Moon,
SJ., Perrimon, N., Nam, J-W. and Shim, J. (2020) Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila.
Nature Communications. 11(1):4483.
• Lee, D., Zdraljevic, S., Cook, DE., Frézal, L., Hsu, J-C., Sterken, MG., Riksen, JAG., Wang, J., Kammenga, JE., Braendle,
C., Félix, M-A., Schroeder, FC. and Andersen, EC. (2019). Selection and gene flow shape niche-associated variation in pheromone response.
Nature Ecology & Evolution 3(10): 1455–1463.
• Crombie, TA., Zdraljevic, S., Cook, DE., Tanny, RE., Brady, SC., Wang, Y., Evans, KS., Hahnel, S., Lee, D., Rodriguez, BC.,
Zhang, G., Zwaag, JVD., Kiontke, KC., and Andersen, EC. (2019). Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic
diversity and admixture with global populations. eLife 8:e50465.
• Lee, D., Yang, H., Kim, J., Brady, S., Zdraljevic, S., Zamanian, M., Kim, H., Paik, YK., Kruglyak, L., Andersen, EC. and Lee, J. (2017).
The genetic basis of natural variation in a phoretic behavior. Nature Communications 8(1): 273(1-7).
• Lee, H., Choi, M., Lee, D., Kim, H., Hwang, H., Kim, H., Park, S., Paik, Y. and Lee, J. (2011). Nictation, a dispersal behavior of the
nematode Caenorhabditis elegans, is regulated by IL2 neurons. Nature Neuroscience 15(1), 107-112.
| Research Grants |
| • 2023~2028 (PI) Reverse engineering of nervous system remodeling, Basic Science Research Program (우수신진연구), NRF of Korea | |
| • 2023 (PI) 무화과-곤충-선충 공생계의 생태적 상호작용 및 공진화 연구, 신진교수 지원 프로그램, 기초과학 자율운영 중점연구소 |
| Lectures |
| • 발생학개론 (Introduction to Developmental Biology) : 학부, 봄학기 | |
| • 오믹스생물학 (Omics Biology) : 학부, 가을학기 | |
| • 동물발생학 특론 (Advanced Animal Developmental Biology) : 대학원(학석1-4기), 가을학기 | |
| • 신경진화생물학 (Evolutionary Neurobiology) : 대학원(석박1-4기), 봄학기 |
| People |
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이보연 |
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| 과정 | 박사후연구원 | |
| 연구실 | 제2과학관 32158B호 | |
| 전화 | 031-290-5953 | |
| 이메일 | lee.boyun@g.skku.edu | |
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김현구 |
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| 과정 | 석박통합과정 | |
| 연구실 | 제2과학관 32158B호 | |
| 전화 | 031-290-5953 | |
| 이메일 | 9enome@g.skku.edu | |
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정은주 |
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| 과정 | 학부연구생 | |
| 연구실 | 제2과학관 32158B호 | |
| 전화 | 031-290-5953 | |
| 이메일 | ppungii99@gmail.com | |
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홍성원 |
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| 과정 | 학부연구생 | |
| 연구실 | 제2과학관 32158B호 | |
| 전화 | 031-290-5953 | |
| 이메일 | tony200202@g.skku.edu | |
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