페이지 정보작성일 21-07-15 16:59
정수명 (Su Myung Jung)
응용 분야: 위 연구를 통해, 현재까지 뚜렷한 치료제가 없는 비만, 지방간 그리고 제2형 당뇨와 같은 대사질환의 예방 및 치료 후보물질을 개발하는 것을 목표로
졸업생들은 바이오 관련 기업(Start-Up 혹은 대기업), 대사질환분야 신약 연구개발 제약회사/정부출연 연구소, 그리고 학계에 취업 할 수 있습니다.
1. Adipose Tissue: “Avengers” or “Thanos” to Our Metabolic Health?Adipose tissue (Fat) regulates body energy homeostasis through the balance between energy storage and expenditure. White Adipose Tissue (WAT) stores and releases energy during eating and fasting but also is more recently recognized as a vital, complex endocrine organ. Brown Adipose Tissue (BAT), which was recently characterized in adults, is activated upon cold exposure and high calorie diet which causes it to burn large amounts of energy, through a unique mechanism. We aim to understand how WAT and BAT uptake and consume a variety of nutrients (e.g. lipid, glucose and amino acids) in order to understand metabolic diseases due to energy imbalance, such as obesity and diabetes. Our long-term goal is to use this knowledge to prevent metabolic diseases including obesity, fatty liver and diabetes, and certain type of cancer
2. How does Metabolism Intersect with Cellular Signaling?
How do metabolism and cell signaling work together to achieve different biological outputs?
Metabolism and signaling pathways have long been studied separately, but recent advances in the field clearly show they are strongly connected. For example, nutrient- and hormone-sensing signaling pathways (e.g. mTOR, Insulin, Growth factors) actively regulate cellular metabolism. Further, metabolism directly regulates gene expression by providing metabolites such as Acetyl-CoA (Histone acetylation) and S-Adenosyl-Methionine (a.k.a. SAM, DNA/Histone methylation) which can be used to epigenetically alter DNA/chromatin packaging and gene expression. Thus, we are interested in identifying mechanisms by which metabolic pathways and signaling pathwayscollaborate to regulate biological processes.
|Academic Employments and Education|
Jung SM, Le J, Doxsey WG, Haley JA, Park G, Jang C, Guertin DA. Stable Isotope Tracing and Metabolomics to Study in vivo Brown Adipose Tissue Metabolic Fluxes.
Methods in Molecular Biology (2022) PMID: 35167094
Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA. In vivo Isotope Tracing Reveals the Versatility of Glucose as a Brown Adipose Tissue Substrate
Cell Reports (2021) Jul. PMID: 34320357
Hsiao WY, Jung SM, Tang Y, Haley JA, Li R, Li H, Martinez Calejman C, Sanchez-Gurmaches J, Hung CM, Luciano AK, DeMambro V, Wellen KE, Rosen CJ, Zhu LJ, Guertin DA. The lipid handling capacity of subcutaneous fat is programmed by mTORC2 during development.
Cell Reports (2020) Oct. PMID: 33027655
Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villén J, Wellen KE, Guertin DA. mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
Nature Communications (2020) Jan. PMID: 31996678
Seo D*, Jung SM*, Park JS, Lee J, Ha J, Kim M, Park SH. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
EBioMedicine (2019) Nov. PMID: 31685442 (*Co-first author)
Jung SM*, Hung CM*, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA. Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Molecular Cell (2019) Aug. PMID: 31442424 (*Co-first author)
Jung SM, Sanchez-Gurmaches J, Guertin DA. Brown Adipose Tissue Development and Metabolism.
Handbook of Experimental Pharmacology (2019) PMID: 30203328
Jung SM andGuertin DA. Insulin PACS a Punch in SIRT1 Activity.
Molecular Cell (2018) Dec. PMID: 30576653
Kim JH, Seo D, Kim SJ, Choi DW, Park JS, Ha J, Choi J, Lee JH, Jung SM, Seo KW, Lee EW, Lee YS, Cheong H, Choi CY, Park SH. The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
EMBO Reports. (2018) Apr. PMID: 29487085
Lee JH *, Jung SM*, Bae E, Yang KM, Park JS, Ahn SG, Ooshima A, Park J, Shin D, Lee Y, Lee S, van Loo G, Kim SJ, Park SH. A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Nature Cell Biology (2017) Oct. PMID: 28892081 (*Co-first author)
Lee P.L*, Jung SM* and Guertin D.A. The Complex Roles of mTOR in Adipocytes and Beyond
Trends in Endocrinology and Metabolism (2017) May. PMID: 28237819 (*Co-first author)
Lee YS, Park JS, Jung SM, Kim SD, Kim JH, Lee JY, Jung KC, Mamura M, Lee SH, Kim SJ, Bae YS, Park SH. Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide.
EMBO Molecular Medicine (2015) May. PMID: 25766838
Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, Mamura M. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.
EMBO Molecular Medicine (2013) Nov. PMID: 24127404
Jung SM, Lee JH, Park J, Oh YS, Lee SK, Park JS, Lee YS, Kim JH, Lee JY, Bae YS, Koo SH, Kim SJ, Park SH. Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.
Nature Communications (2013) Oct. PMID: 24096742
Lee YS, Park JS, Kim JH, Jung SM, Lee JY, Kim SJ, Park SH. Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.
Nature Communications (2011) Sep. PMID: 21897371
• 생명과학2 (Biological Science): 학부, 가을학기
• 생화학연구방법론 (Advanced Biochemical Methodology): 대학원 봄학기 (격년)
• 세포생물학 (Cell Biology): 학부, 봄학기
정수명(Su Myung Jung, Ph.D)
이예린(Yerin Lee, Ph.D Candidate)
이상헌(Sang Hun Lee, Ph.D Candidate)
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