Faculty

정수명 교수님(Su Myung Jung)

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작성일 21-07-15 16:59

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 정수명 (Su Myung Jung)

 직함  조교수
 전공  대사생화학, 분자세포생물학
 연구실  생체대사조절연구실
 전화  031-290-7001
 사무실  제2과학관 32163호
 홈페이지  https://sites.google.com/view/metabolab-skku/home           
 이메일  sumyung.jung@skku.edu
 연구실 소개 
연구분야: 코로나 사태는 우리의 신체활동을 제한하였고, 이는  에너지 대사 불균형으로 인한 대사증후군  대사질환 발병율의 증가를 촉진했습니다. 
우리 연구실은어떻게 하면 맛있는 음식을 충분히 섭취하면서도 건강한 신진대사를 유지할  있을까?” 질문에 대한 답을 제시하고자 합니다.  해답을 
얻기 위해, 우리 몸의 애물단지로만 여겨지던 지방 조직을 깊이 이해하고 이를 활용하여 생체 에너지 대사를 효과적으로 조절하는 연구를 수행하고 있습니다. 
특히 대사 경로  생체 신호 전달 경로를 분석하여, 백색 지방 조직(White Adipose Tissue, WAT) 그리고 갈색 지방 조직(Brown Adipose Tissue, BAT)  
에너지 대사 능력을 조절하는 새로운 분자 기전을 규명 하고자 합니다.   

응용 분야:  연구를 통해, 현재까지 뚜렷한 치료제가 없는 비만, 지방간 그리고 2 당뇨와 같은 대사질환의 예방  치료 후보물질을 개발하는 것을 목표로 

합니다.

취업 분야: 초고령화 사회로 접어든 시대에, 삶의 질을 좌우하는 대사성 질환의 예방  치료 연구에 관한 수요는 앞으로도 꾸준히 증가할  입니다.  

졸업생들은 바이오 관련 기업(Start-Up 혹은 대기업), 대사질환분야 신약 연구개발 제약회사/정부출연 연구소, 그리고 학계에 취업   있습니다. 

                                                 

 Research Background
We use a multidisciplinary approach spanning from genetic animal models to metabolomics and isotope tracing to classic biochemistry to discover key metabolic and signaling mechanisms critical for human metabolic health and disease.  Our research interests are below.
           

1. Adipose Tissue: “Avengers” or “Thanos” to Our Metabolic Health?

Adipose tissue (Fat) regulates body energy homeostasis through the balance between energy storage and expenditure.  White Adipose Tissue (WAT) stores and releases energy during eating and fasting but also is more recently recognized as a vital, complex endocrine organ.  Brown Adipose Tissue (BAT), which was recently characterized in adults, is activated upon cold exposure and high calorie diet which causes it to burn large amounts of energy, through a unique mechanism.  We aim to understand how WAT and BAT uptake and consume a variety of nutrients (e.g. lipid, glucose and amino acids) in order to understand metabolic diseases due to energy imbalance, such as obesity and diabetes. Our long-term goal is to use this knowledge to prevent metabolic diseases including obesity, fatty liver and diabetes, and certain type of cancer

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2. How does Metabolism Intersect with Cellular Signaling?

 

How do metabolism and cell signaling work together to achieve different biological outputs?

      

Metabolism and signaling pathways have long been studied separately, but recent advances in the field clearly show they are strongly connected.  For example, nutrient- and hormone-sensing signaling pathways (e.g. mTOR, Insulin, Growth factors) actively regulate cellular metabolism. Further, metabolism directly regulates gene expression by providing metabolites such as Acetyl-CoA (Histone acetylation) and S-Adenosyl-Methionine (a.k.a. SAM, DNA/Histone methylation) which can be used to epigenetically alter DNA/chromatin packaging and gene expression.  Thus, we are interested in identifying mechanisms by which metabolic pathways and signaling pathwayscollaborate to regulate biological processes.

 
         

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 Research Interests
• Adipose tissue’s nutrient utilization and its roles in systemic (whole body) metabolic homeostasis.
• Crosstalk between metabolic pathways and cellular signaling.

 Academic Employments and Education
2021 – Present: Assistant Professor, Sungkyunkwan University (SKKU)             
• 2016 – 2021: Postdoctoral Associate, University of Massachusetts Medical School 
• 2015 – 2016: Postdoctoral Fellow, University of Texas MD Anderson Cancer Center                    
2014 – 2015: Postdoctoral Fellow, Sungkyunkwan University (SKKU)      
• 2009 – 2014: Ph.D. in Molecular Cell Biology, Sungkyunkwan University (SKKU)
• 2005 – 2009: B.S. in Biological Sciences, Sungkyunkwan University (SKKU)
                 
 Key Publications
  1. Jung SM, Le J, Doxsey WG, Haley JA, Park G, Jang C, Guertin DA.  Stable Isotope Tracing and Metabolomics to Study in vivo Brown Adipose Tissue Metabolic Fluxes.
     Methods in Molecular Biology (2022) PMID: 35167094

  2. Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA.  In vivo Isotope Tracing Reveals the Versatility of Glucose as a Brown Adipose Tissue Substrate
     Cell Reports (2021) Jul. PMID: 34320357

  3. Hsiao WY, Jung SM, Tang Y, Haley JA, Li R, Li H, Martinez Calejman C, Sanchez-Gurmaches J, Hung CM, Luciano AK, DeMambro V, Wellen KE, Rosen CJ, Zhu LJ, Guertin DA.  The lipid handling capacity of subcutaneous fat is programmed by mTORC2 during development.
     Cell Reports (2020) Oct. PMID: 33027655

  4. Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villén J, Wellen KE, Guertin DA.  mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
     Nature Communications (2020) Jan. PMID: 31996678

  5. Seo D*, Jung SM*, Park JS, Lee J, Ha J, Kim M, Park SH.  The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
     EBioMedicine (2019) Nov. PMID: 31685442 (*Co-first author)

  6. Jung SM*, Hung CM*, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA.  Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
     Molecular Cell (2019) Aug. PMID: 31442424 (*Co-first author)

  7. Jung SM, Sanchez-Gurmaches J, Guertin DA.  Brown Adipose Tissue Development and Metabolism.
     Handbook of Experimental Pharmacology (2019) PMID: 30203328

  8. Jung SM andGuertin DA.  Insulin PACS a Punch in SIRT1 Activity.
     Molecular Cell (2018) Dec. PMID: 30576653

  9. Kim JH, Seo D, Kim SJ, Choi DW, Park JS, Ha J, Choi J, Lee JH, Jung SM, Seo KW, Lee EW, Lee YS, Cheong H, Choi CY, Park SH.  The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
     EMBO Reports. (2018) Apr. PMID: 29487085

  10. Lee JH *, Jung SM*, Bae E, Yang KM, Park JS, Ahn SG, Ooshima A, Park J, Shin D, Lee Y, Lee S, van Loo G, Kim SJ, Park SH.  A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
     Nature Cell Biology (2017) Oct. PMID: 28892081 (*Co-first author)

  11. Lee P.L*, Jung SM* and Guertin D.A.  The Complex Roles of mTOR in Adipocytes and Beyond
     Trends in Endocrinology and Metabolism (2017) May. PMID: 28237819 (*Co-first author)

  12. Lee YS, Park JS, Jung SM, Kim SD, Kim JH, Lee JY, Jung KC, Mamura M, Lee SH, Kim SJ, Bae YS, Park SH.  Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide.
     EMBO Molecular Medicine (2015) May. PMID: 25766838

  13. Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, Mamura M.  Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.
     EMBO Molecular Medicine (2013) Nov. PMID: 24127404

  14. Jung SM, Lee JH, Park J, Oh YS, Lee SK, Park JS, Lee YS, Kim JH, Lee JY, Bae YS, Koo SH, Kim SJ, Park SH.  Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.
     Nature Communications (2013) Oct. PMID: 24096742

  15. Lee YS, Park JS, Kim JH, Jung SM, Lee JY, Kim SJ, Park SH.  Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.
     Nature Communications (2011) Sep. PMID: 21897371

                               
 Lectures
• 생명과학1 (Biological Science): 학부, 봄학기
• 생명과학2 (Biological Science): 학부, 가을학기
• 생화학연구방법론 (Advanced Biochemical Methodology): 대학원 봄학기 (격년)                            
• 세포생물학 (Cell Biology): 학부, 봄학기

                     

People
           

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정수명(Su Myung Jung, Ph.D)                         

과정 조교수                                
오피스 제2과학관 32163호
전화 031-290-7001
이메일 sumyung.jung@skku.edu, sumyung.jung@g.skku.edu
                                                                     


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이예린(Yerin Lee, Ph.D Candidate)         

과정 박사과정
연구실 제2과학관 32210호                              
전화 031-299-4503                      
이메일 yrlee95@skku.edu

                 


이상헌.jpg                        

이상헌(Sang Hun Lee, Ph.D Candidate)         

과정 석박통합과정
연구실 제2과학관 32210호
전화 031-299-4503
이메일 amsanghun@skku.edu
                       


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