Faculty

박석희 교수님(Seok Hee Park)

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작성일 21-07-15 16:07

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 박석희 (Seok Hee Park)
 직함
 전공
 연구실
 전화
 사무실
 이메일 
  교수
  분자세포생물학
  세포성장조절연구실
  031-290-5912
  제2과학관 32366
  parks@skku.edu
 
 Research Background
 Our group mainly focuses on the molecular mechanisms of transforming growth factor (TGF)-beta superfamily-mediated signaling pathway. TGF-beta superfamily includes bone morphogenic protein (BMP), activin, and inhibin as well as TGF-beta. These are multifunctional cytokines which play critical roles in a variety of cellular functions such as cell proliferation, apoptosis, immune cell regulation, cancer progression, anti-inflammatory function and stem cell biology. TGF-beta, among this family, transmit the signals through a canonical pathway, composed of TGF-beta type II/ type I receptors with serine-threonine kinase activities and intracelluar signaling proteins, called Smads, as well as a non-canonical pathways using non-Smad intracellular signaling proteins such as TRAF6, TAK1 and RhoA. Currently we are interested in four areas of TGF-beta biology. 1. Molecular mechanisms of TGF-beta-mediated anti-inflammatory function regarding innate immunity, 2. Negative regulation of non-canonical pathway of TGF-beta signaling. 3. Novel mechanism of TGF-beta-induced epithelial-mesenchymal transition (EMT) regarding invasion and metastasis, 4. A role of TGF-beta signaling in mesenchymal stem cells. Ultimately, our aim is to explore the molecular clues of pathogenesis of human diseases such as cancer and inflammatory diseases in terms of TGF-beta signaling and to find molecular targets to treat these diseases.
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 Peer review paper
  1. Jung, S.M., Lee, J.H., Park, J., Oh, Y.S., Lee, S.K., Park, J.S., Lee, Y.S., Kim, J.H., Lee, J.Y., Bae, Y.S., Koo, S.H., Kim, S.J., Park, S.H.* (2013) Smad6 inhibits non-canonical TGF-beta1 signalling by recruiting the deubiquitinase A20 to TRAF6. Nat. Commun. Oct 7;4:2562. doi: 10.1038/ncomms3562.
  2. Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, Mamura M. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.(2013) EMBO Mol. Med. 5(11):1720-39
  3. Lee, H.J., Kim, J.H., Kim, J.H., Martinus, R.D., Park, S.H. (2013) Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism. Biochem. Biophys. Res. Commun.430:981- 986
  4. Lim, S., Bae, E., Kim, H.S., Kim, T.A., Byun, K., Kim, B., Hong, S., Im, J.P., Yun, C., Lee, B., Lee B, Park, S.H., Letterio, J., Kim, S.J. (2012) TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor. PLoS One 7(3):e32705
  5. Kang,Y.J., Shin, J.W., Yoon, J.H., Oh, I.H., Lee, S.P., Kim, S.Y., Park, S.H., Mamura, M. (2012) Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells. Biochem. Biophys. Res. Commun.423:750-756
  6. Kang, H.S., Lee, S.C., Park, Y.S., Jeon, Y.E., Lee, J.H., Jung, S.Y., Park, I.H., Jang, S.H., Park, H.M., Yoo, C.W., Park, S.H., Han, S.Y., Kim, K.P., Kim, Y.H., Ro, J., and Kim, H.K. (2011) Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype. BMC Cancer 11:465
  7. Kim, S.J., Shin, J.Y., Lee, K.D., Bae, Y.K., Choi, I.J., Park, S.H., and Chun, K.H. (2011) Gallectin-3 facilitates cell motility in gastric cancer by up-regulating Protease-Activated Receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1). PLoS ONE  6(9): e25103. doi:10.1371/journal.pone.0025103
  8. Lee, Y.S., Park, J.S., Kim, J.H., Jung, S.M., Lee, J.Y., Kim, S.J., and Park, S.H.* (2011) Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling. Nat. Commun. 2:460. doi:10.1038/ncomms1469.
  9. Kim, S.J., Shin, J.Y., Cheong, T.C., Choi, I.J., Lee, Y.S., Park, S.H., and Chun, K.H. (2011) Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of β-catenin in gastric cancer Clin Exp Metastasis.
  10. Kim, J.H., Sung, K.S., Jung, S.M., Lee, Y.S., Kwon, J.Y., Choi, C.Y., and Park, S.H.* (2011) Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9. Mol Cells. 31(1):85-89.
  11. Lee, Y.S., Kim, J.H., Kim, S.T., Kwon, J.Y., Hong, S., Kim, S.J., and Park, S.H.* (2010) Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-beta1-induced negative regulation of IL-1R/TLR signaling.Biochem. Biophys. Res. Commun.393:836-843
  12. Kim, S.J., Choi, I.J., Cheong, T.C., Lee, S.J., Lotan, R., Park, S.H., and Chun, K.H. (2010) Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression. Gastroenterology 138:1035-1045
  13. Lee, E.K., Jeon, W.K., Chae, M.Y., Hong, H.Y., Lee, Y.S., Kim, J.H., Kwon, J.Y., Kim, B.C., and Park, S.H.* (2010) Decreased expression of glutaredoxin 1 is required for transforming growth factor-beta1-mediated epithelial-mesenchymal transition of EpRas mammary epithelial cells. Biochem. Biophys. Res. Commun.391:1021-1027
  14. Hong, J.H., Lee, G.T., Lee, J.H., Kwon, S.J., Park, S.H., Kim, S.J., and Kim, I.Y. 2009. Effect of bone morphogenetic protein-6 on macrophages. Immunology 128:e442-450
  15. Lee, E.K., Lee, Y.S., Lee, H., Choi, C.Y., and Park, S.H.* 2009. 14-3-3epsilon protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cells. Exp. Mol. Med. 41:453-461
  16. Ryu, J.K., Piao, S., Shin, H.Y., Choi, M.J., Zhang, L.W., Jin, H.R., Kim, W.J., Han, J.Y., Hong, S.S., Park, S.H., Lee, S.J., Kim, I.H., Lee, C.R., Kim, D.K., Mamura, M., Kim, S.J., and Suh, J.K. (2009) IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease. J. Sex. Med. 6:1284-1296
  17. Lee, H., Kwak, H.J., Cho, I.T., Park, S.H., and Lee, C.H. (2009) S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response. Biochem Biophys Res Commun. 378:32-36        
  18. Zhang, L.W., Piao, S., Choi, M.J., Shin, H.Y., Jin, H.R., Kim, W.J., Song, S.U., Han, J.Y., Park, S.H., Mamura, M., Kim, S.J., Ryu, J.K., and Suh, J.K. (2008) Role of increased penile expression of transforming growth factor-beta1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. J. Sex. Med. 5:2318-2329        
  19. Lee, S.A., Park, S.H. and Kim, B.C. (2008) Raloxifene, a selective estrogen receptor modulator, inhibits lipopolysaccharide-induced nitric oxide production by inhibiting the phosphatidylinositol 3-kinase/Akt/nuclear factor-kappa B pathway in RAW264.7 macrophage cells. Mol. Cells 26:48-52        
  20. Piao, S., Ryu, J.K., Shin, H.Y., Zhang, L., Song, S.U., Han, J.Y., Park, S.H., Kim, J.M., Kim, I.H., Kim, S.J., and Suh, J.K. (2008) Repeated intratunical injection of adenovirus expressing transforming growth factor-beta1 in a rat induces penile curvature with tunical fibrotic plaque: a useful model for the study of Peyronie's disease. Int. J. Androl. 31: 346-353        
  21. Lee, Y.S., Lee, E.K., Han, I.O., and Park, S.H.* (2008) Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse epithelial cells. Exp. Mol. Med. 40:43-51        
  22. Lee, E.K., Lee, Y.S., Han, I.O., and Park, S.H.* (2007) Expression of Caveolin-1 reduces cellular responses to TGF-beta1 through down-regulating the expression of TGF-beta type II receptor gene in NIH3T3 fibroblast cells. Biochem Biophys Res Commun. 359:385-390        
  23. Hong, S., Lim, S., Li, A.G., Lee, C. Lee, Y.S. Lee, E.-K., Park, S.H., Wang, X.-J., and Kim, S.-J. (2007) Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nature Immunol. 8:504-513        
  24. Jung, J.W. Hwang, S.Y., Hwang, J.S., Oh, E.S., Park, S.H., and Han, I.O. (2007) Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells. Eur. J. Cancer. 43:1214-1224        
  25. Ku, J.-L., Park, S.H., Yoon, K.-A., Shin, Y.-K., Kim, K.-H., Choi, J.-S., Kang, H.-C., Kim, I.-J., Han, I.-O., and Park, J.-G. (2007) Genetic alterations of the TGF-β signaling pathway in colorectal cancer cell lines: A novel mutation in Smad3 associated with the inactivation of TGF-β-induced transcriptional activation. Cancer Lett. 247:283-92.          
  26. Choi. K.-C., Lee, Y.S., Lim, S., Choi, H.K., Lee, C.-H., Lee, E.-K., Hong, S., Kim, I.-H., Kim, S.-J., and Park, S.H.* (2006)Smad6 negatively regulates interleukin-1 receptor-Toll-like Receptor signaling through direct interaction with the adaptor Pellino-1. Nature Immunol. 7:1057-65          
  27. Kwak, H., Kim, S.H., Yoo, H.G., Park, S.H., and Lee, C.-H. (2005) Jun activation domain-binding protein 1 is required for hyperphosphorylation of 53BP1 upon mitotic checkpoint activation. J. Cancer Biol. Clin. Oncol. 131:789-96.        
  28. Ju, E.M., Choi, K.-C., Hong, S.-H., Lee, C.-H., Kim, B.-C., Kim, S.-J., Kim, I.-H., and Park, S.H.* (2005) Apoptosis of Mink lung epithelial cells by co-treatment of low-dose Staurosporine and Transforming Growth Factor-b1 depends on the enhanced TGF-b signaling and requires the decreased phosphorylation of PKB/Akt. Biochem. Biophys. Res. Commun328:1170-1181.        
  29. Choi, K-.C., Lee, S., Kwak, S.Y., Kim, M-.S., Choi, H.K., Kim, K.H., Chung, J.H., and Park, S.H.* (2005) Increased expression of 14-3-3e protein in intrinsically aged and photoaged human skin in vivo. Mech. Age. Dev. 126: 629-636        
  30. Park, S.H.* (2005) Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads. J. Biochem. Mol. Biol. 38(1):9-16        
  31. Park S.H.*, Kim, B.-C.*, Lee, H.-J.*, Lee, S.R., Karpova, T.S., McNally, J.G.,  Felici, A., Lee, D. K., and  Kim, S.-J. 2004. Jab1/CSN5, a component of the COP9 signalosome, regulates TGF-beta signaling by binding to Smad7 and promoting its degradation. Mol. Cell. Biol. 24(6): 2251-2262. (* co-first authors)        
  32. Kim, B.-C., Kim, H. E., Cha, J.-S., Park, S. H., Yufit, T., Kim, S.-J., and Falanga, V., 2003. Fibroblasts from chronic wounds show altered TGF-beta-signaling due to decreased TGF-beta type II receptor expression. J. Cell. Physiol. 195(3):331-6.        
  33. Hong SH, Lee GD, Chung JY, Cho KS, Park SH, Kim IH, and Jeong JS. 2002. Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver. Exp Mol Med 34(5):361-6        
  34. Park MJ, Kim MS, Park IC, Kang HS, Yoo H, Park SH, Rhee CH, Hong SI, and Lee SH., 2002. PTEN suppresses Hyaluronic Acid Induced Matrix Metalloproteinase-9 Expression in U87MG Glioblastoma Cells through Focal Adhesion Kinase Dephosphorylation, Cancer Res. 62(21):6318-22.        
  35. Park, S. H.*, Lee, S. R., Kim, B.C.,  Cho, E. A., Patel, S. P., Kang, H.-B., Sausville, E.A., Nakanishi, O., Trepel, J. B., Lee, B.I., and Kim, S.-J. 2002. Transcriptional Regulation of the TGF-ß Type II Receptor Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y in Human Breast Cancer Cells. J Biol Chem.  277:5168-74        
  36. Hahm, K.-B., Im, Y.-H., Parks, T. W., Park, S. H., Markowitz, S., Jung, H. Y., Green, J., and  Kim, S.-J. 2001. Loss of TGF-beta Signaling in the Intestine Contributes to Tissue Injuries in Inflammatory Bowel Disease.  Gut  49:190-198        
  37. Lee, D. K., Park, S. H., Yi, Y., Choi, S.-G., Lee, C., Parks, W. T., Cho, H., de Caestecker, M. P., Shaul, Y., Roberts, A. B., and Kim, S.-J. 2001. The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct  interaction with smad4: potential mechanism of HBV-induced liver fibrosis. Genes & Dev. 15:455-466        
  38. Park, S. H.*, Kim, Y. S., Park, B.-K., Hourgaad, S., and Kim, S.-J. 2001. A Sequence-Specific Enhancer Binding Protein Is Responsible for the Differential Expression of  ERT/ELF-3/ESX/ESE-1/jen in Human Gastric Cancer Cell Lines: Implication of the loss of TGF-b type II receptor expression. Oncogene 20:1235-1245        
  39. Park, S. H.*, Lee, B. I.*, Kim, J. W., Sausville, E. A., Kim, H. T., Nakanishi, O., Trepel, J. B., and Kim, S.-J. 2001. MS-275, an histone deacetylase inhibitor, selectively induces TGF-ß type II receptor expression in human breast cancer cells. Cancer Res. 61:931-934 (co-first author)
  40. Park, S. H.*, Birchenall-Roberts, M. C., Yi, Y., Lee, B. I., Lee, D. G., Bertolette, D. C., Fu, T., Ruscetti, F., and Kim, S.-J. 2001. Mechanism of Induction of TGF-b Type II Receptor Gene Expression by v-Src in Murine Myeloid Cells. Cell Growth & Differentiation. 22:9-18
  41. Park, S.H., S.S. Koh., J. H. Chun., H. J. Hwang., and H. S. Kang. 1999. Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:2044-2050.
  42. Ahn, J.H., Park, S.H., and Kang, H,S. 1995. Inactivation of the UAS1 of STA1 by glucose and STA10 and identification of two loci, SNS1 and MSS1, involved in STA10-dependent repression in Saccharomyces cerevisiae. Mol. Gen. Genet. 246:529- 537.
 
 Funding history
• 2012 - 2015  Study about the negative regulation of TGF-beta non-canonical pathway by inhibitory Smad6 
(National Research Foundation, Korea)
• 2011 - 2016
Functional Characterization of the mesenchymal stem cells responsible for the regcognition of immune microenvironmemt 
and resolution of the inflammation (National Research Foundation, Korea)
• 2009 - 2014 Elucidation of TGF-beta signaling pathways for controlling inflammation. (National Research Foundation, Korea)
• 2007 - 2012 Control of the inflammatory diseases involved in innate immunity and pathological inflammation by using the inhibitory
Smads 
(National Research Foundation, Korea)
 
 Education and experiences               
• 2013 - Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2007 - 2013 Associate Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2003 - 2007 Assistant Professor, College of Medicine Inha University
• 2001 - 2003 Senior Research Investigator, National Cancer Center, Korea
• 1998 - 2001 Postdoc, National Cancer Institute, NIH (USA)
• 1998 Ph.D., Dept. of Microbiology, Seoul National University
• 1991 M.S., Dept. of Microbiology, Seoul National University
• 1989 B.S., Dept. of Microbiolgy, Seoul National University
 
 Professional activities
 Member:        Korea Society of Molecular and Cellular Biology; Korea Society of Biochemistry and Molecular Biolgogy

 Lecture
• 감염반응생물학 (Infection and cell signaling): 학부 대상, 가을 학기(격년)
• 유전공학 (Genetic Engineering): 학부 대상, 봄 학기(격년)
• 분자의과학 특론 (Advance in Molecular Medicine): 대학원 대상, 가을 학기(격년)
• 의과학연구방법론 (Experimental Methods in Medical Sciences): 대학원 대상, 봄 학기(격년)
 
 People
Post-doctoral fellows   
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 이연숙 (Dr. Youn Sook Lee)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제
 
  박사후연구원
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  bioys@skku.edu
  Therapeutic development of inflammatory diseases involved of innate immunity and
  pathological inflammation by the inhibitory Smad protein
 
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 정수명 (Dr. Su Myung Jung)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  박사후연구원
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  smjung@skku.edu
  Regulation of BMP signaling through DUBs
 
Graduate students

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 이재영 (Jae Young Lee)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  박사과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  ljy861008@naver.com
  Regulatory mechanism of inflammasome signaling pathway
 
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 김준환 (Jun Hwan Kim)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  박사과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  Lacid1017@naver.com
  Functional study of Pellino proteins
 
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 박진석 (Jin Seok Park)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  박사과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  <" _mce_href="mailto:ezs7777@naver.com<">ezs7777@naver.com
  Therapeutic mechanisms of mesenchymal stem cells in inflammatory diseases
 
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 이지형 (Ji Hyung Lee)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  석박통합과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  wlgud1990@skku.edu
  Regulation of TGF-β1-induced EMT
 
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 김준형 (Jun Hyeong Kim)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  석박통합과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  jh50116@naver.com
  Functions of TGF-β in mesenchymal stem cell differentiation
 
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 정세희 (Se Hee Jung)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  석박통합과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  tpgml9212@naver.com
  Regulation of non-canonical TGF-β signaling pathway
 
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 서동엽 (Dong Youb Seo)
 과정
 연구실
 전화
 사무실
 이메일
 연구주제 
  석박통합과정
  세포성장조절연구실
  031-299-4500
  제2과학관 32316
  jimina@naver.com
  Regulation of BMP signaling through DUBs
 
   

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