Faculty

이석희 교수님(Lee SH Yi)

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작성일 21-04-27 17:30

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이석희.jpg

 이석희 (Lee SH Yi)

직함 교수                              
전공 세포생물학                            
연구실 세포생물학연구실                                  
전화 031-290-7005                
사무실 제2과학관 32114              
이메일             shlee@skku.edu
 
  Research Background
1. Analysis on the mechanisms of acrosome reaction in mammalian spermatozoa
The main focus of the research is to identify and characterize the membrane-bound progesterone receptor in spermatozoa which is involved in acrosome reaction, and elucidate how signal mediated by this receptor is transduced via intracellular signaling pathway to induce acrosome reaction.
2. Mammalian sperm maturation in epididymis
The research is focused on the characterization of the changes in the proteins of spermatozoa   during epididymal maturational process of spermatozoa. The proteins which showed significant changes during maturational process are selected and characterized further employing the proteomics tools in relation to their physiological implication of fertilization.
3. Molecular characterization of the sperm proteases
The main interest of this project is to characterize the several acrosomal proteases which are presumed to play important roles during fertilization process. The research is focused on the analysis of the peptide sequences and cDNA sequences of the selected acrosomal proteases.
 

 

이석희본문.jpg

 
 Peer review paper
• Kyunhee Park, Seunghye Jeon, Yoon-Jae Song, Lee S.H.Yi (2012). Proteomics analysis of boar spermatozoa and quantity changes of superoxide dismutase1, glutathione peroxidase, and peroxiredoxin 5 during epididymal maturation. Animal Reprod.Sci.135:53-61
• Hyun-Kyung Yu, Ho-Jeong Lee, Jin-Hyung Ahn, In-Hwan Lim, Jae-Hoon Moon, Yeup Yoon, Lee S.H. Yi, Sun Jin Kim, and Jang-Seong Kim (2013). Immunoglobullin Fc domain fusion to apoliporoteins(a) kringle V significantly prolongs plasma half-life without affecting its anti-angiogenic activity. Protein Engineering, Design & Selection 
26:425-432.
• S Jang and L S H Yi (2005). Identification of a 71 kDa protein as a putative non-genomic membrane progesterone receptor in boar spermatozoa. J.Endocrinal.1
84:417-425            
 
 Funding history
• Proteomic analysis of boar spermatozoa during epididymal maturation (2005) Grant supported by Korea Science Foundation.
• Molecular characterization of the regulatory mechanisms induced by endocrine and exocrine factors on sperm maturation, capacitation, and acrosomal reaction (2002-2004) Grant supported by Korea Science Foundation. 

  

 Education and experiences
• 1993 Professor, Dept. of Biological Science, Sungkyunkwan University
• 1992 - 1993 Research Associate, Dept. of Genetics, Washington Univ. School of Medicine
• 1988 - 1992 Research Associate, Dept. of Ob/Gyn, Washington Univ. School of Medicine
• 1988 Ph.D., Dept. of Physiology and Biophysics, Univ. of Illinois at Urbana-Champaign
• 1984 M.S., Dept. of Physiology and Biophysics, Univ. of Illinois at Urbana-Champaign    
• 1982 M.S., Dept. of Zoology, Seoul National Univ.               
• 1980

B.S., Dept. of Zoology, Seoul National Univ.             

 Professional activities
• Member, Society for the Study of Reproduction
• Member, Korean Society fort Molecular and Cellular Biology
• Member, The Genetics Society of Korea

 Lecture
• 세포생물학 (Cell Biology): 학부 대상, 봄 학기 
• 세포생물학실험 (Cell Biology Laboratory): 학부 대상, 봄 학기 
• 생식생물학 (Human Reproduction): 학부 대상, 가을 학기 
• 분자세포생물학 (Molecylar Cell Biology): 학부/대학원 대상, 가을 학기 
• 생명과학1, 2 (Biological Science): 학부 대상, 봄/가을 학기
• 분자세포생물학연구방법론 (Methods in Molecular Cell Biology): 대학원 대상, 가을 학기

 

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