박영민 교수님(Yong Min Park)

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작성일 21-04-27 17:29




 박영민 (Young Min Park)










 제2과학관 32209





  Research Background
A Role of Annexins and Phospholipase A2 in the Regulation of Insulin Secretion

Annexins are a superfamily of proteins that are expressed in the majority of mammalian cells as well as molds and plants. A notable characteristic of all the members is that they bind to phospholipids in a Ca2+-dependent manner. Various annexins play a regulatory role in the exocytosis of secretory vesicles in adrenal chromaffin cells, anterior pituitary cells, and pancreatic ß-cells. In these cells, intracellulaf annexins play a role in the regulation of exocysis of secretory vesicles. However, the regulatory mechanisms of intracellular annexin I on the secretory machinery have yet to be fully explained.

The phopholipase A2 (PLA2, phosphatide 2-acylhydrolase, EC is a superfamily of distinct enzymes that catalyze specifically the hydrolysis of the sn-2 eter bond of phospholipids to yield free fatty acids and lysophospholipids. PLA2 enzymes have been implicated to play a role in various cellular processes and responses such as phospholipid digestion and metabolism, membrane remoldelling, host defense, differentiation, mitogenesis,exocytosis, and cytotoxicity.

 We currently investigate the regulatory mechanisms of annexins and phospholipase A2 on the insulin secretion in pancreatic islets and insulimona cells to gain an insight into its mode of action.


Binding of annexin l to the surface of islet cells

 Peer review paper
• Na-na Kang, Jong Hak Won and Young Min Park, Annexin I stimulates Insulin secretion through regulation of cytoskeleton and PKC activity. 2009, Animal Cells and Systems, 13:17-23. 
• Myung-Ki Lee, Hye-Jung Yang, Byoung-Mok Kim, Ae-Ri-Jo and Young-Min Park, Inhibition of browning and preference improvements of Dioscorea batatas through the addition of sugar alcohols and organic acids. 2009, J. Food Sci. Nutri., 14:220-225. 
• Dongkoo Lee, Jong Hak Won, Chung-Kyoon Auh and Young Min Park, Purification and characterization of cytosolic phospholipase A2 from rat liver.2003,Mol.Cells, 16:361-367 
• Jong Hak Won, Na-na Kang, Chung-Kyoon Auh and Young Min Park, The surface receptor is involved in annexin I-stimulated insulin secretion in MIN6N8a cells. 2003, Biochem. Biophys. Res. Commun., 307:389-394. 
• Shin-Hee Hong, Jong Hak Won, Seung-Ah Yoo, Chung-Kyoon  Auh, and Young Min Park, Effect of annexin I on insulin secretion through surface binding sites in rat pancreatic islets. 2002, FEBS let., 532-17-20 
 Education and experience
1993 - Professor, Dept.of Biological Science, Sungkyunkwan University
1989 Ph.D., Dept. of Biology, Sungkyunkwan University
1984 M.S., Dept. of Biology, Sungkyunkwan University
1981 B.S., Dept. of Biology, Sungkyunkwan University



동물발생학 (Animal Development): 학부 대상, 봄 학기
동물생리학 (Animal Physiology): 학부 대상, 가을 학기
동물생리학실험 (Animal Physiology Laboratory): 학부 대상, 가을 학기
동물생리학특론 (Advanced Animal Physiology): 대학원 대상, 봄 학기
동물발생학특론 (Advanced Animal Development): 대학원 대상, 가을 학기
내분비학 (Endocrinology): 대학원 대상


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