Faculty

배용수 교수님(Yong-Soo Bae)

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작성일 21-04-27 17:28

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      배용수.jpg  배용수 (Yong-Soo Bae)
직함 교수 (Professor)
전공 바이러스학 면역학 (Virology and Immunology)
연구실 바이러스학 (Virology Lab)
전화 031-290-5911
사무실 제1종합연구동 81510호
홈페이지 http://shb.skku.edu/skkuvirus/ 

이메일

 

ysbae04@skku.edu

 

 
 Research Background

Dendritic cell Biology and Immunology

1) Dendritic cell (DC) differentiation from bone marrow or hematopoietic stem cells
2) Epigenetic control of DC-specific gene expressions during DC development
3) DC-mediated immune responses
(Th1/Th2/Th17)
4) DC-mediated immune tolerance mechanism
5) DC subtypes and their specific genes and their functions. 

Oral-Mucossal Vaccine with Polioirus Vector System(RPS-VAX)

1) Oral HBV therapeutic vaccine
2) Dendritic cell-mediated long-term immunity of poliovirus vaccine

 Peer review paper

2019

Seung-Phil Shin, A-RA Goh, Hyeon-Gu Kang, Seok-Jun Kim, Jong-Kwang Kim, Kyung-Tae Kim, John H Lee, Yong-Soo Bae*, Yuh-Seog Jung* and Sang-Jin Lee*. CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation. Cancers 11(10):1583 DOI: 10.3390/cancers11101583 (2019)

- Sunil Kumar, Yideul Jeong, Mahammad Umer Ashraf and Yong-Soo Bae, Dendritic Cell-Mediated Th2 Immunity and Immune Disorders. Int J Mol Sci. 20(9): 2159, p1-28. (2019 May)

- Topic Editors:Yong-Soo Bae, Eui-Cheol Shin, Yoe-Sik Bae and Willem van Eden. STRESS AND IMMUNITY. (Book) Editorial: Stress and Immunity, Yong-Soo Bae, Eui-Cheol Shin, Yoe-Sik Bae and Willem Van Eden. Frontiers in Immunology, March 2019.

-  Mahammad Umer Ashraf, Yideul Jeong Seung-Eon Roh and Yong-Soo BaeTransendothelial migration (TEM) of in vitro generated dendritic cell vaccine in cancer immunotherapy. Arch. Pharm. Res. (2019) 42:582–590. (Review)

2018

Seung-Eon Roh, Yideul Jeong, Myeong-Ho Kang and Yong-Soo Bae. Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy. Cancer Letters 434: 196-205 (2018. 7) https://doi.org/10.1016/j.canlet.2018.07.029

2017

- Jeong-Hoon Lee, Won Young Tak, Yoon Lee, Min-Kyu Heo, Jae-Sung Song, Hak-Yeop Kim, Soo Young Park, Si Hyun Bae, Joon Hyeok Lee, Jeong Heo, Ki-Hwan Kim, Young-Soo Bae, Yoon Jun Kim. Immunotherapy with Autologous Dendritic Cells for Hepatocellular Carcinoma, Randomised Phase II study. Oncoimmunology 6:7, e1328335-1~12, DOI:10.1080/2162402X.2017.1328335

- Myungeun Lee, Jaewon Yang, Eunji Jo, Ji-Young Lee, Hee-Young Kim, Jong Yeon Hwang, Ralf Bartenschlager, Eui-Cheol Shin, Yong-Soo Bae* and Marc P. Windisch*. A Novel Inhibitor IDPP Interferes with Entry and Egress of Hepatitis C Virus by Targeting Glycoprotein E1 in a Genotype-Specific MannerScientific Report. 7:44676 (2017) | DOI: 10.1038/srep44676

- Md. Selim Ahmed, Myeong-Ho Kang, Ezra Lee, Yujin Park, Yideul Jeong and Yong-Soo Bae.  SH2 domain-containing adaptor protein B expressed in dendritic cells is involved in T cell homeostasis by regulating DC-mediated Th2 immunity Clin Exp. Vaccine Res. 6:50-60

2016

- YoungHyun Shin, Hoyong Lim, Byeong-Sun Choi, Kyung-Chang Kim, Chun Kang, Yong-Soo Bae and Cheol-Hee Yoon. Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs. Virology Journal (2016) 13:141-DOI 10.1186/s12985-016-0595-2 (2016. Aug 16)

- Don G. Lee, Beom K. Choi b, Young H. Kim, Ho S. Oh, Sang H. Park, Yong Soo Bae and Byoung S. Kwon. The repopulating cancer cells in melanoma are characterized by increased mitochondrial membrane potential Cancer Letters

- YoungHyun Shin, Hoyong Lim, Byeong-Sun Choi, Kyung-Chang Kim, Chun Kang, Yong-Soo Bae and Cheol-Hee Yoon. Highly activated p53 contributes to selectively increased apoptosis of latently HIV-1 infected cells upon treatment of anticancer drugs. Virology Journal (2016) 13:141-DOI 10.1186/s12985-016-0595-2

- Lee M, Yang J, Park S, Jo E, Kim HY, Bae YS, Windisch MPMicrococcin P1, a naturally occurring macrocyclic peptide inhibiting hepatitis C virus entry in a pan-genotypic mannerAntiviral research 132: 287-295

- Jin Il Km, You-Jin Kim, Philippe Lemey, Joon-Yong Bae, Donghwan Kim, Ilseob Lee, Sehee Park, Hyejin Kim, Seok-Il Jang, Jeong-Sun Yang, Hak Kim, Dae-Won Kim, Jeong-Gu Nam, Sung Soon Kim, Kisoon Kim, Jae Myun Lee, Man Ki Song, Daesub Song, Jun Chang, Kee-Jong Hong, Yong-Soo Bae, Jin-WonSong, Joo-Shil Lee and Man-SeongPark. The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination. Scientific reports.(2016).

- Md. Selim Ahmed and Yong-Soo Bae. Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside. Immune network.(2016).

2015

- Md. Selim Ahmed, Se Eun Byeon, Yideul Jeong, Mohammad Alam Miah, Md Salahuddin, Yoon Lee, Sung-Soo Park & Yong-Soo Bae. Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy. OncoImmunology.(2015): e984550.

- Jinjoo Lee, Se Eun Byeon, Ju Yeol Jung, Myeong-Ho Kang, Yu-Jin Park, Kyeong-Eun Jung, and Yong-Soo Bae. Azasugar-Containing Phosphorothioate Oligonucleotide (AZPSON) DBM-2198 Inhibits Human Immunodeficiency Virus Type 1 (HIV-1) Replication by Blocking HIV-1 gp120 without Affecting the V3 Region. Molecules and cells.(2015)): 122.

- Cheol-Hee Yoon, Sang-Yoon Kim, Se Eun Byeon, Yideul Jeong, Jinjoo Lee, Kwang Pyo Kim, Jinseu Park, Yong-Soo Bae. p53-derived host restriction of HIV-1 replication by protein kinase R-mediated tat phosphorylation and inactivation. Journal of virology.(2015)): 4262-4280.

- Ho S. Oh, Beom K. Choi, Young H. Kim, Don G. Lee, Sunhee Hwang, Myoung J. Lee, Sang H. Park, Yong-Soo Bae and ByoungS.Kwon. 4-1BB signaling enhances primary and secondary population expansion of CD8+ T cells by maximizing autocrine IL-2/IL-2 receptor signaling. PloS one.(2015).

- Jun-Eui Park, Jinah Jang, Ji-Hye Choi, Mi-sun Kang, Yun-Ju Woo, Young-Rim Seong, Chan-Bum Choi, Hye-Soon Lee, Sang-Cheol Bae and Yong-Soo Bae. DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice. Journal of immunology research.(2015).

- Seung-Soo Han, Jinjoo Lee, Yideul Jung, Myeong-Ho Kang, Jung-Hyub Hong, Min-Suk Cha, Yu-Jin Park, Ezra Lee, Cheol-Hee Yoon, Yong-Soo Bae. Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system. Vaccine.(2015): 4827-4836.

- Jeong-Hoon Lee, Minjong Lee, Yoon Lee, Min Kyu Heo, Jae-Sung Song, Ki-Hwan Kim, Hyunah Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Yong-Soo Bae* and Yoon Jun Kim*. Phase I/II study of adjuvant immunotherapy with tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. British J. Cancer.(2015): 1666-1676.

2014

- Ahmed, Md, and Yong-Soo Bae. Dendritic cell-based therapeutic cancer vaccines: past, present and future. Clinical and experimental vaccine research.(2014): 113-116

- Gi Soo Youn, Dong-Joo Kwon, Sung Mi Ju, Hyangshuk Rhim, Yong-Soo Bae,SooYoungChoi, JinseuPark.Yong-Soo Bae. Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes. Toxicology and applied pharmacology.(2014): 42-52

2013

- Mohammad Alam Miah, Se-Eun Byeon, Md Selim Ahmed, Cheol-Hee Yoon, Sang-Jun Ha, and Yong-Soo Bae.  Egr2 Induced during DC Development Acts as an Intrinsic Negative Regulator of DC Immunogenicity. Eur. J. Immunol.

- Mohammad Alam Miah and Yong-Soo Bae. Regulation of DC development and DC-mediated T-cell immunity via CISH. Oncoimmunology 2(3): 000 -000 (2013).

- Heung Kyu Lee and Yong-Soo Bae. 12th International Dendritic Cell Symposium October 7–11, 2012; Daegu, Korea (New Paradigm of Dendritic Cell Science and Application). Meeting Report Oncoimmunology, 2(2): 1-7 (2013).

- Seung-Pil Shin, Hye-Hyun Seo, Jae-Hun Shin, Hyung-Bae Park, Dong-Pyo Lim, Hyeon-Seok Eom, Yong-Soo Bae, In-Hoo Kim, Kyungho Choi and Sang-Jin Lee . Adenovirus Expressing Both Thymidine Kinase and Soluble PD1 Enhances Antitumor Immunity by Strengthening CD8 T-cell Response. Mol Ther. 2013 Jan 22. doi: 10.1038/mt.2012.252.

2012

- Fujimasa Tada, Masanori Abe*, Masashi Hiroka, Yoshiou Ikeda1, Yoichi Hiasa, Yoon Lee, Nam-Chul Jung, Woo-Bok Lee, Hyun-Soo Lee, Yong-Soo Bae* and Morikazu Onji.  Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. Int. J. Oncol 41(5):1601-9 (accepted June 29, 2012 Sep On-line publ)

- Sung Mi Ju, Ah Ra Goh, Dong-Joo Kwon, Gi Soo Youn, Hyung-Joo Kwon1, Yong Soo Bae2,
Soo Young Choi, and Jinseu Park. Extracellular HIV-1 Tat Induces Human Beta-Defensin-2 Production Via NF-kappaB/AP-1 Dependent

Pathways in Human B Cells. Mol. Cells 33, 335-341, April 30, (2012)

- Nam-Chul Jung, Hee Jung Kim, Mi-Sun Kang, Jun-Ho Lee, Jie-Young Song, Han Geuk Seo, Yong-Soo Bae, Dae-Seog Lim. Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors. Cancer Letters 324(1):58-65 (2012)

- Mohammad Alam Miah, Cheol-Hee Yoon, Joonoh Kim, Jinah Jang, Young-Rim Seong and Yong-Soo Bae.CISH is induced during DC development and regulates DC-mediated CTL activation. Eur.J. Immunol. 42(1):58-68 (2012)

 

 Funding history
• 2016 - 2021
The novel hepatitis B viral therapeutics of multi-step viral life cycle inhibition combined with immune-
modulation (KMoHW Emerging infectious Disease G# HI16C1074)
• 2015 - 2020 Blood-restricted fx-expressing Novel Dendritic Cells Controlling Immune Homeostasis in the Blood (Samsung Future
Technology Foundation G# BA150107767)
• 2012 - 2017  Establishment and application of the core technology to induce dendritic cell differentiation through the genomic study
of stem cell differentiation: Bio & Medical Technology Development Grant of the National Research Foundation
(GNo. 2012M3A9B402826).
• 2009 - 2012 Study on the mechanisms of latent infection of HIV-1 and pathogenesis of AIDS-related dementia in connection with PKR
and Tat: Basic Research Grant of the National Research Foundation (NRF) (No 2009-0084683)

 Education and experiences
•  2003 Professor, Dept. of Biological Science, Sungkyunkwan University
• 1993 - 2003 Assistant/Associate/full Professor, Dept. of Microbiology, Hannam University
• 1991 - 1993 Postdoc, Dana-Farber Cancer Institute, Harvard Medical School
• 1990 Ph.D., Dept. of Microbiology and Infectious Disease, Faculty of Medicine, University of Calgary
• 1983 M.S., Dept. of Microbiology, Seoul National University
• 1981 B.S., Dept. of Microbiology, Seoul National University
 
 Education and experiences
Vice-President:       Korean Society of Virology,. 
Vice-President:      The Korean Vaccine Society
Committee Member: Korean Association of Immunology
 
 Lectures
생명과학 (Biology): 학부 대상, 봄 학기
Virus 학 (Virology and Lab): 학부 대상, 봄 학기
수지상세포 생물학 (Dendritic cell biology): 대학원 대상, 격년 가을 학기      
바이러스성 암학 (Viral Oncology): 대학원 대상, 격년 가을 학기
바이러스성 질환 (Viral Diseasea): 대학원 대상, 격년 가을 학기      
ADIS and Human Retrovirology: 대학원 대상, 격년 가을 학기
 
 People

Current People

Sunil.jpg

 Sunil Kumar

  Course

Research Fellow

 E-mail

sunilkumar@skku.edu

 Reach Area 

Epigenetic control of DC developent, DC immunotherapy

 

 

 

 

 

 

 


Dongyeob_Seo.jpg

 Dongyeob Seo

  Course 

Ph.D Fellow

 E-mail 

sdy2080@skku.edu

 Reach Area 

Epigenetic regulation of DC differentiation

 

 

 

 

 

 

 


UMER.jpg

 Ashraf. Muhammad Umer

  Course 

Ph.D course

 E-mail 

drumerashraf@gmail.com

 Reach Area 

DC-mediated immunotherapy and vaccine

 

 

 

 

 

 

 



Yideul.jpg

 Yideul Jung

  Course 

M.S-Ph.D joint program

 E-mail 

skyiller@gmail.com

 Reach Area 

Dendritic cell subset and immunobiology

 

 

 

 

 

 

 


Jinju.jpg

 

 Jinjoo Lee

  Course 

M.S-Ph.D joint program

 E-mail 

ljj0441@gmail.com

 Reach Area 

Functional study of dendritic cells

 

 

 

 

 

 

 


minsuk.jpg

  Min-Suk Cha              

  Course 

M.S-Ph.D joint program

 E-mail 

hyunisle@gmail.com

 Reach Area 

Molecular study of dendritic cells

 

 

 

 

 

 

 

Myeongho.jpg

  Myung-Ho Kang              

  Course 

M.S-Ph.D joint program

 E-mail 

mho231@nate.com

 Reach Area 

Lung-specific dendritic cells

 

 

 

 

 

 

 


hong.jpg

  Jung-Hyub Hong              

  Course 

M.S-Ph.D joint program

 E-mail 

natureius@naver.com

 Reach Area 

Molecular study of dendritic cells

 

 

 

 

 

 

 


Ye-Ji_Kim.jpg

  Ye-ji Kim              

  Course 

M.S course

 E-mail 

kyw07043@gmail.com

 Reach Area 

Oral vaccine development

 

 

 

 

 

 

 



Former People

12.jpg

 Md Selim Admed(Ph.D.)

 


  

 2015년 2월 졸업 (박사)

 이메일

 selimpstu476@gmail.com

 연구주제

 Molecular study on dendritic cell differentiation 

 

  

 


13.jpg

 정주열 (Ju Yeol Jung)

 

 

 

 2015년 8월 졸업 (석사)

 이메일

 canon-d@nate.com

 연구주제

  Molecular study on dendritic cell differentiation

 


 


 

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