Faculty

배외식 교수님(Yoe-Sik Bae)

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작성일 21-04-27 17:24

본문


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 배외식 (Yoe-Sik Bae) 

 직함

 교수

 전공

 면역학 약리학

 연구실

 감염 및 염증질환 연구실

 전화

 031-290-5914

 사무실

 제2과학관 32302B

 이메일

 yoesik@skku.edu 

 

  


 Research Background
We are interested in the development of bioactive molecules that can be used to treat infectious or inflammatory diseases. Our major target diseases include polymicrobial sepsis, rheumatoid arthritis, inflammatory bowel disease, and colon cancer. To generate useful target molecules that can be used to develop therapeutic agents against these infectious or inflammatory diseases, we are focusing on several chemoattractant G-protein coupled receptors (GPCRs). Since leukocyte trafficking in vivo is a crucial event that modulate immune and inflammatory responses, and chemotactic GPCRs mediate these response, the receptors can be considered as important primary targets to control infectious or inflammatory disorders. Currently, we are testing the effects and mechanism of action of chemotactic GPCR ligands against these diseases in experimental animal models.

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Sepsis is a serious life-threatening infectious disease. More than 200,000 deaths have been caused annually by sepsis in the US. Since there is no effective therapeutic agents against sepsis at this time point, scientists are trying to identify useful target molecule to control sepsis. We are investigating some chemoattractant GPCRs including formyl peptide receptors and CXCR2 as important targets for the development of therapeutic agents against sepsis.

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 Peer review paper
  1. Lee HY, Jeong YS, Lee M, Kweon HS, Huh YH, Park JS, Hwang JE, Kim K, Bae YS. Intracellular formyl peptide receptor regulates naïve CD4 T cell migration. Biochem Biophys Res Commun. 2018;497:226-32.

  2. Bae GH, Lee SK, Kim HS, Lee M, Lee HY, Bae YS. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017;49:e407.

  3. Park MY, Kim HS, Lee M, Park B, Lee HY, Cho EB, Seong JY, Bae YS. FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2. Sci Rep. 2017;7:15575.

  4. Park YJ, Kim HS, Lee HY, Hwang JS, Bae YS. A novel antimicrobial peptide isolated from centipede Scolopendra subspinipes mutilans stimulates neutrophil activity through formyl peptide receptor 2. Biochem Biophys Res Commun. 2017;494:352-7.

  5. Kim JC, Jung YS, Lee HY, Park JS, Bae YS. Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling. Exp Mol Med. 2017;49:e369.

  6. Lee HY, Lee M, Bae YS. Formyl Peptide Receptors in Cellular Differentiation and Inflammatory Diseases. J Cell Biochem. 2017;118:1300-7.

  7. Kim YS, Ok CY, Park JS, Lee HY, Bae YS. Phospholipase Cγ1 suppresses foreign body giant cell formation by maintaining RUNX1 expression in macrophages. Biochem Biophys Res Commun. 2017;482:1025-9.

  8. Park YJ, Lee SK, Jung YS, Lee M, Lee HY, Kim SD, Park JS, Koo J, Hwang JS, Bae YS. Promotion of formyl peptide receptor 1-mediated neutrophil chemotactic migration by antimicrobial peptides isolated from the centipede Scolopendra subspinipes mutilans. BMB Rep. 2016;49:520-5.

  9. Ghim J, Chelakkot C, Bae YS, Suh PG, Ryu SH. Accumulating insights into the role of phospholipase D2 in human diseases. Adv Biol Regul. 2016;61:42-6.

  10. Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS. Serum amyloid A inhibits RANKL-induced osteoclast formation. Exp Mol Med. 2015;47:e194.

  11. Lee SK, Kim SD, Kook M, Lee HY, Ghim J, Choi Y, Zabel BA, Ryu SH, Bae YS. Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2. J Exp Med. 2015;212:1381-90.

  12. Lee SK, Park YJ, Ko MJ, Wang Z, Lee HY, Choi YW, Bae YS. A novel natural compound from garlic (Allium sativum L.) with therapeutic effects against experimental polymicrobial sepsis. Biochem Biophys Res Commun. 2015;464:774-9.

  13. Park YJ, Lee HY, Jung YS, Park JS, Hwang JS, Bae YS. Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1. BMB Rep. 2015;48:479-84.

  14. Lee YS, Park JS, Jung SM, Kim SD, Kim JH, Lee JY, Jung KC, Mamura M, Lee S, Kim SJ, Bae YS, Park SH. Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide. EMBO Mol Med. 2015 Mar 12;7(5):577-92.

  15. Yoon JH, Kim D, Jang JH, Ghim J, Park S, Song P, Kwon Y, Kim J, Hwang D, Bae YS, Suh PG, Berggren PO, Ryu SH. Proteomic analysis of the palmitate-induced myotube secretome reveals involvement of the annexin A1-formyl peptide receptor 2 (FPR2) pathway in insulin resistance. Mol Cell Proteomics. 2015;14:882-92.

  16. Kook M, Lee SK, Kim SD, Lee HY, Hwang JS, Choi YW, Bae YS. Anti-septic activity of α-cubebenoate isolated from Schisandra chinensis. BMB Rep. 2015;48:336-41.

  17. Lee N, Jung YS, Lee HY, Kang N, Park YJ, Hwang JS, Bahk YY, Koo J, Bae YS. Mouse neutrophils express functional umami taste receptor T1R1/T1R3. BMB Rep. 2014;47:649-54.

  18. Lyu JH, Park DW, Huang B, Kang SH, Lee SJ, Lee C, Bae YS, Lee JG, Baek SH. RGS2 suppresses breast cancer cell growth via a MCPIP1-dependent pathway. J Cell Biochem. 2015;116:260-7.

  19. Park S, Kim SD, Lee HY, Hwang D, Park JS, Bae YS, Chung J. A novel delivery platform for therapeutic peptides. Biochem Biophys Res Commun. 2014;450:13-8.

  20. Lee HY, Kim H, Lee SY, Jung YS, Kim SD, Bae YSA membrane-tethering pepducin that inhibits formyl peptide receptor 2-induced signaling. Pharmazie. 2014;69:293-6.
     
  21. Park SY, Seetharaman R, Ko MJ, Kim do Y, Kim TH, Yoon MK, Kwak JH, Lee SJ, Bae YS, Choi YW. Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokine production by inducing heme oxygenase-1 in RAW264.7 cells. Int Immunopharmacol. 2014;19:253-61.
     
  22. Lee HY, Oh E, Kim SD, Seo JK, Bae YS. Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2. Biochem Biophys Res Commun. 2014;443:1003-7.
     
  23. Park SY, Bae YS, Ko MJ, Lee SJ, Choi YW. Comparison of anti-inflammatory potential of four different dibenzocyclooctadiene lignans in microglia; action via activation of PKA and Nrf-2 signaling and inhibition of MAPK/STAT/NF-κB pathways. Mol Nutr Food Res. 2014;58:738-48
     
  24. Heo SC, Kwon YW, Jang IH, Jeong GO, Yoon JW, Kim CD, Kwon SMBae YS, Kim JH. WKYMVm-induced activation of formyl peptide receptor 2 stimulates ischemic neovasculogenesis by promoting homing of endothelial colony-forming cells. Stem Cells. 2014;32:779-90.
     
  25. Park SY, Park TG, Lee SJ, Bae YS, Ko MJ, Choi YW. α-Iso-cubebenol inhibits inflammation-mediated neurotoxicity and amyloid beta 1-42 fibril-induced microglial activation. J Pharm Pharmacol. 2014;66:93-105.
     
  26. Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH. Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials. 2014;35:578-89.
     
  27. Jung SM, Lee JH, Park J, Oh YS, Lee SK, Park JS, Lee YS, Kim JH, Lee JY, Bae YS, Koo SH, Kim SJ, Park SH. Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6. Nat Commun. 2013;4:2562.
     
  28. Kim SD, Kwon S, Lee SK, Kook M, Lee HY, Song KD, Lee HK, Baek SH, Park CB, Bae YS. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp Mol Med. 2013;45:e40.
     
  29. Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Cell Signal. 2013;25:2147-54.
     
  30. Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS. Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils. Exp Mol Med. 2013;45:e27.
     
  31. Lee HY, Kim SD, Baek SH, Choi JH, Cho KH, Zabel BA, Bae YS. Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation. Biochem Biophys Res Commun. 2013;433:255-9
     
  32. Lee HY, Kim SD, Baek SH, Choi JH, Cho KH, Zabel BA, Bae YS. Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation. Biochem Biophys Res Commun. 2013;433:18-23.
     
  33. Jung YS, Lee SK, Ok CY, Cho EJ, Park JS, Choi YW, Bae YS. Role of CXCR2 on the immune modulating activity of α-iso-cubebenol a natural compound isolated from the Schisandra chinensis fruit. Biochem Biophys Res Commun. 2013;431:433-6.
     
  34. Park DW, Lee HK, Lyu JH, Chin H, Kang SW, Kim YJ, Bae YS, Baek SH. TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway. Biochem Biophys Res Commun. 2013;430:933-7.
     
  35. Park DW, Lyu JH, Kim JS, Chin H, Bae YS, Baek SH. Role of JAK2-STAT3 in TLR2-mediated tissue factor expression. J Cell Biochem. 2013;114:1315-21.
     
  36. Kim JM, Moon SH, Park SJ, Lee HY, Hong KS, Seo J, Bae YS, Chung HM. Pertussis toxin enhances colony organization of enzymatic-dissociated single human embryonic stem cells. Stem Cells Dev. 2013;22:307-19.
     
  37. Lee SK, Kim SD, Kook M, Lee HY, Park JS, Park YH, Kang JS, Jung WJ, Choi YW, Bae YS. Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis. Biochem Biophys Res Commun. 2012;427:547-52.
     
  38. Lee SK, Kim SD, Lee HY, Baek SH, Ko MJ, Son BG, Park S, Choi YW, Bae YS. α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis. Biochem Biophys Res Commun. 2012;426:226-31.
     
  39. Kim SD, Kim HJ, Shim JW, Lee HY, Lee SK, Kwon S, Jung YS, Baek SH, Park JS, Zabel BA, Bae YS. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. J Immunol. 2012;189:2000-5.
     
  40. Jang SY, Shin YK, Lee HY, Park JY, Suh DJ, Kim JK, Bae YS, Park HT. Local production of serum amyloid a is implicated in the induction of macrophage chemoattractants in Schwann cells during wallerian degeneration of peripheral nerves. Glia. 2012;60:1619-28.
     
  41. Kim SD, Lee HY, Shim JW, Kim HJ, Baek SH, Zabel BA, Bae YS. A WKYMVm-containing combination elicits potent anti-tumor activity in heterotopic cancer animal model. PLoS One. 2012;7:e30522.
     
  42. Tae YM, Park HT, Moon HG, Kim YS, Jeon SG, Roh TY, Bae YS, Gho YS, Ryu SH, Kwon HS, Kim YK. Airway activation of formyl peptide receptors inhibits Th1 and Th17 cell responses via inhibition of mediator release from immune and inflammatory cells and maturation of dendritic cells. J Immunol. 2012;188:1799-808.
     
  43. Park DW, Lee HK, Jeong TW, Kim JS, Bae YS, Chin BR, Baek SH. The JAK2-Akt-glycogen synthase kinase-3β signaling pathway is involved in toll-like receptor 2-induced monocyte chemoattractant protein-1 regulation. J Immunol. 2012;188:1799-808.
     
  44. Lim EJ, Park DW, Jeong TW, Chin BR, Bae YS, Baek SH. TRAIL is involved in CpG ODN-mediated anti-apoptotic signals. Oncol Rep. 2012;27:1213-8.
     
  45. Lee HK, Park DW, Bae JH, Kim HJ, Shin DG, Park JS, Lee JG, Lee SJ, Bae YS, Baek SH. RGS2 is a negative regulator of STAT3-mediated Nox1 expression. Cell Signal. 2012;24:803-9.
     
  46. Bae GH, Lee HY, Jung YS, Shim JW, Kim SD, Baek SH, Kwon JY, Park JS, Bae YS. Identification of novel peptides that stimulate human neutrophils. Exp Mol Med. 2012;44:130-7.
     
  47. Kim SD, Lee HY, Shim JW, Kim HJ, Yoo YH, Park JS, Baek SH, Zabel BA, Bae YS. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011;184:243-51.
     
  48. Kim AJ, Kim HJ, Jee HJ, Song N, Kim M, Bae YS, Chung JH, Yun J. Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks. Biochim Biophys Acta. 2011;1813:1230-8.
     
  49. Shin MK, Jang YH, Yoo HJ, Kang DW, Park MH, Kim MK, Song JH, Kim SD, Min G, You HK, Choi KY, Bae YS, Min do S. N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow. J Biol Chem. 2011;286:17133-43.
     
  50. Lee HY, Lee SY, Kim SD, Shim JW, Kim HJ, Jung YS, Kwon JY, Baek SH, Chung JBae YS. Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. J Immunol. 2011;186:4347-53.
     
  51. Shim JW, Lee HY, Kim SD, Kim HJ, Baek SH, Park JS, Kim SG, Choi, YW, Bae YS. Chloroform extract of garlic (Allium sativum) stimulates production of superoxide anion and CXCL8 in human neutrophils. Hort Environ Biotechnol. 2011;52:218-23.
     
  52. Kim SD, Kim YK, Lee HY, Kim YS, Jeon SG, Baek SH, Song DK, Ryu SH, Bae YS. The agonists of formyl peptide receptors prevent development of severe sepsis after microbial infection. J Immunol. 2010;185:4302-10.
     
  53. Lee HY, Kim SD, Shim JW, Kim HJ, Kwon JY, Kim JM, Baek SH, Park JS, Bae YS. Activation of human monocytes by a formyl peptide receptor 2-derived pepducin. FEBS Lett. 2010;584:4102-8.
     
  54. Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH. Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression. Exp Mol Med. 2010;42:712-20.
     
  55. Lee HK, Yeo S, Kim JS, Lee JG, Bae YS, Lee C, Baek SH. Protein kinase C-eta and phospholipase D2 pathway regulates foam cell formation via regulator of G protein signaling 2. Mol Pharmacol. 2010;78:478-85.
     
  56. Kim JS, Yeo S, Shin DG, Bae YS, Lee JJ, Chin BR, Lee CH, Baek SH. Glycogen synthase kinase 3beta and beta-catenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages. FEBS J. 2010;277:2830-7.
     
  57. Lee MJ, Kim J, Kim MY, Bae YS, Ryu SH, Lee TG, Kim JH. Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells. J Proteome Res. 2010;9:1754-62.
     
  58. Lee HY, Kim SD, Shim JW, Kim HJ, Yun J, Baek SH, Kim K, Bae YS. A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production. Exp Mol Med. 2010;42:302-9.
     
  59. Lee YJ, Park SY, Kim SG, Park da J, Kang JS, Lee SJ, Yoon S, Kim YH, Bae YS, Choi YW. Identification of a novel compound that inhibits iNOS and COX-2 expression in LPS-stimulated macrophages from Schisandra chinensis. Biochem Biophys Res Commun. 2010;391:1687-92.
     
  60. Kim SD, Kim JM, Jo SH, Lee HY, Lee SY, Shim JW, Seo SK, Yun J, Bae YS. Functional expression of formyl peptide receptor family in human NK cells. J Immunol. 2009;183:5511-7.
     
  61. Shim JW, Jo SH, Kim SD, Lee HY, Yun J, Bae YS. Lysophosphatidylglycerol inhibits formyl peptide receptorlike-1-stimulated chemotactic migration and IL-1beta production from human phagocytes. Exp Mol Med. 2009;41:584-91.
     
  62. Jee HJ, Kim HJ, Kim AJ, Bae YS, Bae SS, Yun J. UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS. Biochem Biophys Res Commun. 2009;383:358-62.
     
  63. Lee HY, Kim SD, Shim JW, Lee SY, Yun J, Bae YS. LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils. Exp Mol Med. 2009;41:325-33.
     
  64. Lee HY, Kim SD, Shim JW, Yun J, Kim K, Bae YS. Activation of formyl peptide receptor like-1 by serum amyloid A induces CCL2 production in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2009;380:313-7.
     
  65. Lee YJ, Shim JW, Lee YJ, Park YH, Lee HY, Kim SD, Choi YW, Bae YS. Identification of a novel compound that stimulates intracellular calcium increase and CXCL8 production in human neutrophils from Schisandra chinensis. Biochem Biophys Res Commun. 2009;379:928-32.
     
  66. Kim MA, Kim HJ, Jee HJ, Kim AJ, Bae YS, Bae SS, Yun J. Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation. Oncogene. 2009;28:1241-7.
     
  67. Kim MK, Kim SD, Lee HY, Lee SY, Shim JW, Yun J, Kim JM, Min do S, Yoo YH, Bae YS. Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling. FEBS Lett. 2008;582:3379-84
     
  68. Lee HY, Kim SD, Shim JW, Lee SY, Lee H, Cho KH, Yun J, Bae YS. Serum amyloid A induces CCL2 production via formyl peptide receptor-like 1-mediated signaling in human monocytes. J Immunol. 2008;181:4332-9.
     
  69. Lee MY, Kim HJ, Kim MA, Jee HJ, Kim AJ, Bae YS, Park JI, Chung JH, Yun J. Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation. Cell Cycle. 2008;7:2705-9.
     
  70. Jo JY, Kim HL, Lee YK, Tomura H, Bae YS, Okajima F, Im DS. N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. J Pharmacol Sci. 2008l;107:303-7.
     
  71. Han M, Lim SM, Kim YL, Kim HL, Kim K, Sacket SJ, Jo JY, Bae YS, Okajima F, Im DS. Albumin and antioxidants inhibits serum-deprivation-induced cell adhesion in hematopoietic cells. Biomol Ther. 2008;16:410-5.
     
  72. Lee SY, Lee HY, Kim SD, Jo SH, Shim JW, Lee HJ, Yun J, Bae YS. Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells. Biochem Biophys Res Commun. 2008;374:147-51.
     
  73. Lee SC, Chung IM, Jin YJ, Song YS, Seo SY, Park BS, Cho KH, Yoo KS, Kim TH, Yee SB, Bae YS, Yoo YH. Momilactone B, an allelochemical of rice hulls, induces apoptosis on human lymphoma cells (Jurkat) in a micromolar concentration. Nutr Cancer. 2008;60:542-51.
     
  74. Jo SH, Kim SD, Kim JM, Lee HY, Lee SY, Shim JW, Yun J, Im DS, Bae YS. Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells. Biochem Biophys Res Commun. 2008;372:147-51.
     
  75. Lee HY, Bae YS. The anti-infective peptide, innate defense-regulator peptide, stimulates neutrophil chemotaxis via a formyl peptide receptor. Biochem Biophys Res Commun. 2008;369:573-8.
     
  76. Shin MK, Kim MK, Bae YS, Jo I, Lee SJ, Chung CP, Park YJ, Min do S. A novel collagen-binding peptide promotes osteogenic differentiation via Ca2+/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells. Cell Signal. 2008;20:613-24.
     
  77. Lee SY, Lee MS, Lee HY, Kim SD, Shim JW, Jo SH, Lee JW, Kim JY, Choi YW, Baek SH, Ryu SH, Bae YS. F2L, a peptide derived from heme-binding protein, inhibits LL-37-induced cell proliferation and tube formation in human umbilical vein endothelial cells. FEBS Lett. 2008;582:273-8.
     
  78. Jung EM, Lee TJ, Park JW, Bae YS, Kim SH, Choi YH, Kwon TK. The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. Apoptosis. 2008;13:133-45.
     
  79. Yi KS, Lee S, Kang YH, Bae YS, Hwang SY, Ha I, Kim H, Kim MS, Cho B, Kang HJ, Bang KT, Kim JY, Yang J, Chung J, Ahn C. Weak response of porcine C5a receptor towards human C5a in miniature pig endothelial cells and PMNs. Xenotransplantation. 2007;14:563-71.
     
  80. Lee SY, Lee HY, Kim SD, Shim JW, Bae YS. Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2007;363:490-4.
     
  81. Park KS, Lee HY, Lee SY, Kim MK, Kim SD, Kim JM, Yun J, Im DS, Bae YS. Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor. FEBS Lett. 2007;581:4411-6.
     
  82. Lee MY, Kim MA, Kim HJ, Bae YS, Park JI, Kwak JY, Chung JH, Yun J. Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: implications in cancer cell death. Biochem Biophys Res Commun. 2007;360:483-9.
     
  83. Lee HY, Lee SY, Shin EH, Kim SD, Kim JM, Lee MS, Ryu SH, Bae YS. F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling. Biochem Biophys Res Commun. 2007;359:985-90.
     
  84. Chang YJ, Kim YL, Lee YK, Sacket SJ, Kim K, Kim HL, Han M, Bae YS, Okajima F, Im DS. Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts. Prostaglandins Other Lipid Mediat. 2007;83:268-76.
     
  85. Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J. Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. Exp Mol Med. 2007 ;39:205-12.
     
  86. Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS. Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins. Exp Mol Med. 2007;39:185-94.
     
  87. Kim MK, Min do S, Park YJ, Kim JH, Ryu SH, Bae YS. Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells. FEBS Lett. 2007;581:1917-22.
     
  88. Park KS, Kim MK, Lee HY, Kim SD, Lee SY, Kim JM, Ryu SH, Bae YS. S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. Biochem Biophys Res Commun. 2007;356:239-44.
     
  89. Lee JG, Lee SH, Park DW, Bae YS, Yun SS, Kim JR, Baek SH. Phosphatidic acid as a regulator of matrix metalloproteinase-9 expression via the TNF-alpha signaling pathway. FEBS Lett. 2007;581:787-93.
     
  90. Jo SH, Yun J, Kim JM, Lee C, Baek SH, Bae YS. Serum amyloid A induces WISH cell apoptosis. Acta Pharmacol Sin. 2007;28:73-80.
     
  91. Park KS, Kim MK, Im DS, Bae YS. Effect of lysophosphatidylglycerol on several signaling molecules in OVCAR-3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor. Biochem Pharmacol. 2007;73:675-81.
     
  92. Kim YL, Im YJ, Lee YK, Ha NC, Bae YS, Lim SM, Okajima F, Im DS. Albumin functions as an inhibitor of T cell adhesion in vitro. Biochem Biophys Res Commun. 2006;351:953-7.
     
  93. Lee HY, Shin EH, Bae YS. Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. Acta Pharmacol Sin. 2006;27:1359-66.
     
  94. Shin EH, Lee HY, Bae YS. Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis. Biochem Biophys Res Commun. 2006;348:606-11.
     
  95. Lim EJ, Lee SH, Lee JG, Chin BR, Bae YS, Kim JR, Lee CH, Baek SH. Activation of toll-like receptor-9 induces matrix metalloproteinase-9 expression through Akt and tumor necrosis factor-alpha signaling. FEBS Lett. 2006;580:4533-8.
     
  96. Lee HY, Jo SH, Lee C, Baek SH, Bae YS. Differential production of leukotriene B4 or prostaglandin E2 by WKYMVm or serum amyloid A via formyl peptide receptor-like 1. Biochem Pharmacol. 2006;72:860-8.
     
  97. Kim JI, Lee HY, Park KS, Lee T, Ryu SH, Bae YS. A small compound that inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production. Biochem Biophys Res Commun. 2006;347:797-802.
     
  98. Kim MK, Lee HY, Kwak JY, Park JI, Yun J, Bae YS. Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. Biochem Biophys Res Commun. 2006;345:67-73.
     
  99. Aosai F, Rodriguez Pena MS, Mun HS, Fang H, Mitsunaga T, Norose K, Kang HK, Bae YS, Yano A. Toxoplasma gondii-derived heat shock protein 70 stimulates maturation of murine bone marrow-derived dendritic cells via Toll-like receptor 4. Cell Stress Chaperones. 2006;11:13-22.
     
  100. Lee HY, Kim MK, Park KS, Shin EH, Jo SH, Kim SD, Jo EJ, Lee YN, Lee C, Baek SH, Bae YS. Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes. Mol Pharmacol. 2006;70:241-8.
     
  101. Ahn BH, Min G, Bae YSBae YS, Min DS. Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. Exp Mol Med. 2006;38:55-62.
     
  102. Kim Y, Lee BD, Kim O, Bae YS, Lee T, Suh PG, Ryu SH. Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl peptide receptor-like 1. J Immunol. 2006;176:2969-75.
     
  103. Shin EH, Lee HY, Kim SD, Jo SH, Kim MK, Park KS, Lee H, Bae YS. Trp-Arg-Trp-Trp-Trp-Trp antagonizes formyl peptide receptor like 2-mediated signaling. Biochem Biophys Res Commun. 2006;341:1317-22.
     
  104. Lee CJ, Han JS, Seo JY, Park HT, Kwon HC, Jeong JS, Kim IH, Yun J, Bae YS, Kwak JY, Park JI. Pioglitazone, a synthetic ligand for PPARγ, induces apoptosis in PR-deficient human colorectal cancer cells. Apoptosis. 2006;11:401-11.
     
  105. Park KS, Lee HY, Kim MK, Shin EH, Jo SH, Kim SD, Im DS, Bae YS. Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. Mol Pharmacol. 2006;69:1066-73.
     
  106. Kim MK, Lee HY, Park KS, Shin EH, Jo SH, Yun J, Lee SW, Yoo YH, Lee YS, Baek SH, Bae YS. Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. Biochem Pharmacol. 2005;70:1764-71.
     
  107. Lee HY, Park KS, Kim MK, Lee T, Ryu SH, Woo KJ, Kwon TK, Bae YS. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005;336:716-22.
     
  108. Lee KS, Baek DW, Kim KH, Shin BS, Lee DH, Kim JW, Hong YS, Bae YS, Kwak JY. IL-10-dependent down-regulation of MHC class II expression level on monocytes by peritoneal fluid from endometriosis patients. Int Immunopharmacol. 2005;5:1699-712.
     
  109. Lee HY, Kim MK, Park KS, Shin EH, Bae YS. Group IB secretory phospholipase A2 stimulates leukotriene B4 production by a unique mechanism in human neutrophils. Biochem Biophys Res Commun. 2005;334:500-8.
     
  110. Kang HK, Lee HY, Kim MK, Park KS, Park YM, Kwak JY, Bae YS. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. J Immunol. 2005;175:685-92.
     
  111. Shin MH, Lee YA, Bae YS, Kita H, Kim Y, Ryu SH. The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2. Int Arch Allergy Immunol. 2005;137 Suppl 1:21-6.
     
  112. Park KS, Lee HY, Kim MK, Shin EH, Bae YS. Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes. Biochem Biophys Res Commun. 2005;333:353-8.
     
  113. Lee YN, Lee HY, Kim JS, Park C, Choi YH, Lee TG, Ryu SH, Kwak JY, Bae YS. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222:227-35.
     
  114. Lee HY, Kim MK, Park KS, Bae YH, Yun J, Park JI, Kwak JY, Bae YS. Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells. Biochem Biophys Res Commun. 2005;330:989-98.
     
  115. Bae YS, Park EY, Lee HY, Kang HK, Suh PG, Kwak JY, Ryu SH, Lee T. Compounds stimulating cytosolic phospholipase A2 activity with a combinational action mode. Biochem Biophys Res Commun. 2004;325:632-8.
     
  116. Jo EJ, Lee HY, Lee YN, Kim JI, Kang HK, Park DW, Baek SH, Kwak JY, Bae YS. Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-kappa B in human neutrophils. J Immunol. 2004;173:6433-9.
     
  117. Kim GY, Oh WK, Shin BC, Shin YI, Park YC, Ahn SC, Lee JD, Bae YS, Kwak JY, Park YM. Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+ DC and type I helper T cell-dominant immune state. FEBS Lett. 2004;576:391-400.
     
  118. Kim GY, Han MG, Song YS, Shin BC, Shin YI, Lee HJ, Moon DO, Lee CM, Kwak JY, Bae YS, Lee JD, Park YM. Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-kappaB. Biol Pharm Bull. 2004;27:1656-62.
     
  119. Lee HY, Kang HK, Yoon HR, Kwak JY, Bae YS. Lysophosphatidic acid is a mediator of Trp-Lys-Tyr-Met-Val-d-Met-induced calcium influx. Biochem Biophys Res Commun. 2004;324:458-65.
     
  120. Kim JW, Park HY, Lee MJ, Jang MJ, Lee SY, Park YM, Son DH, Chang YC, Bae YS, Kwak JY. Phosphatidic acid and tumor necrosis factor-alpha induce the expression of CD83 through mitogen activated protein kinase pathway in a CD34+ hematopoietic progenitor cell line, KG1. Int Immunopharmacol. 2004;4:1603-13.
     
  121. Park HY, Park JY, Kim JW, Lee MJ, Jang MJ, Lee SY, Baek DW, Park YM, Lee SW, Yoon S, Bae YS, Kwak JY. Differential expression of dendritic cell markers by all-trans retinoic acid on human acute promyelocytic leukemic cell line. Int Immunopharmacol. 2004;4:1587-601.
     
  122. Lee SY, Oh JY, Lee MJ, Jang MJ, Park HY, Kim JW, Min DS, Park YM, Chang YC, Bae YS, Kwak JY. Anti-apoptotic mechanism and reduced expression of phospholipase D in spontaneous and Fas-stimulated apoptosis of human neutrophils. Eur J Immunol. 2004;34:2760-70.
     
  123. Kang HK, Lee HY, Lee YN, Jo EJ, Kim JI, Aosai F, Yano A, Kwak JY, Bae YS. Toxoplasma gondii-derived heat shock protein 70 stimulates the maturation of human monocyte-derived dendritic cells. Biochem Biophys Res Commun. 2004;322:899-904.
     
  124. Jo EJ, Lee HY, Kim JI, Kang HK, Lee YN, Kwak JY, Bae YS. Activation of formyl peptide receptor-like 1 by WKYMVm induces serine phosphorylation of STAT3, which inhibits its tyrosine phosphorylation and nuclear translocation induced by hydrogen peroxide. Life Sci. 2004;75:2217-32.
     
  125. Kim SY, Ahn BH, Kim J, Bae YS, Kwak JY, Min G, Kwon TK, Chang JS, Lee YH, Yoon SH, Min DS. Phospholipase C, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells. Eur J Biochem. 2004;271:3470-80.
     
  126. Bae YS, Lee HY, Jo EJ, Kim JI, Kang HK, Ye RD, Kwak JY, Ryu SH. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol. 2004;173:607-14.
     
  127. Kim JI, Jo EJ, Lee HY, Kang HK, Lee YN, Kwak JY, Bae YS. Stimulation of early gene induction and cell proliferation by lysophosphatidic acid in human amnion-derived WISH cells: role of phospholipase D-mediated pathway. Biochem Pharmacol. 2004;68:333-40.
     
  128. Kang HK, Lee HY, Lee YN, Jo EJ, Kim JI, Kim GY, Park YM, Min DS, Yano A, Kwak JY, Bae YS. Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells. Int Immunopharmacol. 2004;4:911-20.
     
  129. Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY. Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase. Exp Mol Med. 2004;36:172-8.
     
  130. Lee HY, Kang HK, Jo EJ, Kim JI, Lee YN, Lee SH, Park YM, Ryu SH, Kwak JY, Bae YS. Trp-Lys-Tyr-Met-Val-Met stimulates phagocytosis via phospho-lipase D-dependent signaling in mouse dendritic cells. Exp Mol Med. 2004;36:135-44.
     
  131. Lee YN, Lee HY, Kang HK, Kwak JY, Bae YS. Phosphatidic acid positively regulates LPS-induced differentiation of RAW264.7 murine macrophage cell line into dendritic-like cells. Biochem Biophys Res Commun. 2004;318:839-45.
     
  132. Bae YS, Yi HJ, Lee HY, Jo EJ, Kim JI, Lee TG, Ye RD, Kwak JY, Ryu SH. Differential activation of formyl peptide receptor-like 1 by peptide ligands. J Immunol. 2003;171:6807-13.
     
  133. Park SK, Kim GY, Lim JY, Kwak JY, Bae YS, Lee JD, Oh YH, Ahn SC, Park YM. Acidic polysaccharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine dendritic cells. Biochem Biophys Res Commun. 2003;312:449-58.
     
  134. Bae YS, Park EY, Kim Y, He R, Ye RD, Kwak JY, Suh PG, Ryu SH. Novel chemoattractant peptides for human leukocytes. Biochem Pharmacol. 2003;66:1841-51.
     
  135. Bae YS, Song JY, Kim Y, He R, Ye RD, Kwak JY, Suh PG, Ryu SH. Differential activation of formyl peptide receptor signaling by peptide ligands. Mol Pharmacol. 2003;64:841-7.
     
  136. Hur J, Kang MK, Park JY, Lee SY, Bae YS, Lee SH, Park YM, Kwak JY. Pro-apoptotic effect of high concentrations of histamine on human neutrophils. Int Immunopharmacol. 2003;3:1491-502.
     
  137. Bae YS, Park JC, He R, Ye RD, Kwak JY, Suh PG, Ho Ryu S. Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils. Mol Pharmacol. 2003;64:721-30.
     
  138. Kim JI, Jo EJ, Lee HY, Cha MS, Min JK, Choi CH, Lee YM, Choi YA, Baek SH, Ryu SH, Lee KS, Kwak JY, Bae YS. Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. J Biol Chem. 2003;278:31731-6.
     
  139. Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY. Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils. Int Immunopharmacol. 2003;3:835-43.
     
  140. Bae YS, Lee TG, Park JC, Hur JH, Kim Y, Heo K, Kwak JY, Suh PG, Ryu SH. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63:1043-50.
     
  141. Chang YT, Choi G, Bae YS, Burdett M, Moon HS, Lee JW, Gray NS, Schultz PG, Meijer L, Chung SK, Choi KY, Suh PG, Ryu SH. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem. 2002;3:897-901.
     
  142. Park DW, Bae YS, Nam JO, Kim JH, Lee YG, Park YK, Ryu SH, Baek SH. Regulation of cyclooxygenase-2 expression by phospholipase D in human amnion-derived WISH cells. Mol Pharmacol. 2002;6:614-9.
     
  143. Bae YS, Kim Y, Park JC, Suh PG, Ryu SH. The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J Leukoc Biol. 2002;71:329-38.
     
  144. Kim Y, Bae YS, Park JC, Suh PG, Ryu SH. The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells. Exp Mol Med. 2001;33:257-62.
     
  145. Lee CS, Bae YS, Lee SD, Suh PG, Ryu SH. ATP-induced mitogenesis is modulated by phospholipase D2 through extracellular signal regulated protein kinase dephosphorylation in rat pheochromocytoma PC12 cells. Neurosci Lett. 2001;313:117-20.
     
  146. Bae YS, Ryu SH. ATP-induced focal adhesion kinase activity is negatively modulated by phospholipase D2 in PC12 cells. Exp Mol Med. 2001;33:150-5.
     
  147. Bae YS, Bae H, Kim Y, Lee TG, Suh PG, Ryu SH. Identification of novel chemoattractant peptides for human leukocytes. Blood. 2001;97:2854-62.
     
  148. Bae YS, Kim Y, Kim JH, Lee TG, Suh PG, Ryu SH. Independent functioning of cytosolic phospholipase A2 and phospholipase D1 in Trp-Lys-Tyr-Met-Val-D-Met-induced superoxide generation in human monocytes. J Immunol. 2000;164:4089-96.
     
  149. Bae YS, Kim Y, Kim Y, Kim JH, Suh PG, Ryu SH. Trp-Lys-Tyr-Met-Val-D-Met is a chemoattractant for human phagocytic cells. J Leukoc Biol. 1999;66:915-22.
     
  150. Baek SH, Bae YS, Seo JK, Lee YH, Kim JH, Kwun KB, Suh PG, Ryu SH. Trp-Lys-Tyr-Met-Val-Met activates mitogen-activated protein kinase via a PI-3 kinase-mediated pathway independent of PKC. Life Sci. 1999;65:1845-56.
     
  151. Bae YS, Ju SA, Kim JY, Seo JK, Baek SH, Kwak JY, Kim BS, Suh PG, Ryu SH. Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes. J Leukoc Biol. 1999;65:241-8.
     
  152. Seo JK, Bae YS, Song H, Baek SH, Kim BS, Choi WS, Suh PG, Ryu SH. Distribution of the receptor for a novel peptide stimulating phosphoinositide hydrolysis in human leukocytes. Clin Biochem. 1998;31:137-41.
     
  153. Lee JY, Chung YJ, Bae YS, Ryu SH, Kim BH. Synthesis of hexapeptide and tetrapeptide analogues of the immune modulating peptides. J Chem Soc Perkin Trans 1. 1998;359-65
 Current Funding
• 2018 - 2020 PI. Mid-career Researcher Program funded by NRF.
• 2014 - 2019 PI. Grant funded by Samsung Science & Technology Foundation.
• 2017 - 2023 Member. SRC Program funded by NRF

 Education and experiences
• 2014 Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2010 - 2014 Associate Professor, Dept. of Biological Sciences, Sungkyunkwan University
• 2008 - 2009 Visiting Associate Professor, Stanford University School of Medicine
• 2002 - 2010 Full-time Instructor, Assistant Professor, Associate Professor, Dong-A University College of Medicine
• 2000 - 2002 Postdoc, POSTECH
• 2000 Ph.D., Dept. of Life Science, POSTECH
• 1998 M.S., Dept. of Life Science, POSTECH
• 1996 B.Ag., Dept. of Animal Sci. & Technol., Seoul National University

 Professional activities
Senior Editorial
Board Member:
American Journal of Clinical and Experimental Immunology
Editor: Journal of Life Science
Member: American Association of Immunologists, Korean Society of Molecular and Cellular Biology, Korean Society of Biochemistry and
Molecular Biology, Korean Association of Immunologists, Korean Peptide and Protein Society
Committee
Member:
Organizing committee of 12th Dendritic Cell Symposium 2012.
 

 Lecture
중개생물학 (Translational Biology): 학부 대상, 봄 학기
생리활성물질개발론 (Development of Bioactive Molecules): 대학원 대상, 가을 학기
고급생명과학2 (Advanced Biology2): 학부 대상, 가을 학기


 People

감염 및 염증질환 연구실
전화 031-299-4509
위치 제2과학관 32301, 32302A

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 이하영 (Dr. Ha Young Lee) 

 

 

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 연구조교수

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 hayoung@skku.edu

 

 

 


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 정영수 (Young Su Jung) 

 

 

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 박사후 연구원

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 curely@skku.edu

 

 

 


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 이민규 (Mingyu Lee) 

 

 

  과

 석박사통합과정 (삼성융합의과학원)

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 curely@skku.edu

 

 

 


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  김지철 (Ji Chul Kim) 

 

 

  

 석박사통합과정

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 kjc629@skku.edu

 

 

 


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  김형식 (Hyung Sik Kim) 

 

 

  

 석박사통합과정

 이메일

 khs379@naver.com

 

 

 


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  김예선 (Ye Sun Kim) 

 

 

  

 석박사통합과정

 이메일

 pianokys@naver.com

 

 

 


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  박병현 (Byeung Hyun Park) 

 

 

  

 석박사통합과정

 이메일

 exlope123@naver.com

 

 

 


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  박민영 (Min Young Park) 

 

 

  

 석박사통합과정

 이메일

 0206alsdud@hanmail.net

 

 

 


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  배건호 (Geon Ho Bae) 

 

 

  

 석박사통합과정

 이메일

 aromamimo@skku.edu

 

 

 


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  정유선 (Yu Sun Jeong) 

 

 

  

 석박사통합과정

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 yusun2041@gmail.com

 

 

 


 

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